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- W2263125461 abstract "Mycoplasma genitalium, discovered almost 20 years ago, is one of 14 mycoplasmas of human origin and is found predominantly in the genital tract, being sexually transmitted. It is mainly flask-shaped, and the MgPa protein of the narrow terminal portion is instrumental in its attachment to eukaryotic cell surfaces. The terminal structure may also be involved in the gliding movement of M genitalium. It metabolises glucose but not arginine or urea and is susceptible to broad-spectrum antibiotics in a manner similar to M pneumoniae. The M genitalium genome, the smallest known for a self-replicating organism, namely 580 Kb, was the first to be fully sequenced. All the proposed open reading frames of the genome are contained in the M pneumoniae genome, with the latter containing other specific genes. In addition, the MgPa adhesin gene of M genitalium has considerable sequence homology with the P1 adhesin gene of M pneumoniae. Apart from adhesion, invasion of eukaryotic cells by M genitalium has been demonstrated, entrance being mediated apparently by the terminal structure; intracellular location may promote chronic infection and enhance pathogenicity. Thus, apart from acute nongonococcal urethritis, M genitalium is associated with the chronic disease. M genitalium, lacking all the genes for amino acid synthesis, requires an exogenous supply and this probably accounts for the difficulty of primary cultural isolation. Reliable detection is made routinely by means of the polymerase chain reaction (PCR), primers and probes for which are detailed, although PCR technology in combination with cell culture and mycoplasmal medium has resulted in some isolates. (author abstract)" @default.
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- W2263125461 date "2000-01-01" @default.
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- W2263125461 title "The biology of Mycoplasma genitalium" @default.
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