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• W2263136700 abstract "Microgravity has been shown to alter protein kinase C (PKC) activity; therefore, we investigated whether microgravity influences mechanically stimulated Ca(2+) signaling and ATP-induced Ca(2+) oscillations, both of which are modulated by PKC. Rabbit tracheal epithelial outgrowth cultures or suspended epithelial sheets were rotated in bioreactors to simulate microgravity. Mechanical stimulation of a single cell increased the cytosolic Ca(2+) concentration in 35-55 cells of both outgrowth cultures and epithelial sheets kept at unit gravity (G) or in simulated microgravity (smicroG). In outgrowth cultures, 12-O-tetradecanoylphorbol-13-acetate (TPA; 80 nM), a PKC activator, restricted Ca(2+) waves to about 10 cells in unit G and to significantly fewer cells in smicroG. TPA only slightly reduced the spread of Ca(2+) waves in epithelial sheets kept in smicroG but did not inhibit Ca(2+) waves of sheets kept in unit G. In both cell preparations from both conditions, TPA inhibited ATP-induced Ca(2+) oscillations; however, the effect was more pronounced in cells kept in smicroG. These results suggest that PKC activation is more robust in cells subjected to smicroG." @default.
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• W2263136700 date "2000-08-01" @default.
• W2263136700 modified "2023-10-04" @default.
• W2263136700 title "Selected Contribution: PKC activation inhibits Ca²⁺signaling in tracheal epithelial cells kept in simulated microgravity" @default.
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• W2263136700 doi "https://doi.org/10.1152/jappl.2000.89.2.855" @default.
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