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• W2263185714 abstract "Biomedical research and clinical practice are struggling to cope with the growing complexity that the progress of health care involves. The most challenging diseases, those with the largest socioeconomic impact (cardiovascular conditions; musculoskeletal conditions; cancer; metabolic, immunity, and neurodegenerative conditions), are all characterized by a complex genotype–phenotype interaction and by a “systemic” nature that poses a challenge to the traditional reductionist approach. In 2005 a small group of researchers discussed how the vision of computational physiology promoted by the Physiome Project could be translated into clinical practice and formally proposed the term Virtual Physiological Human. Our knowledge about these diseases is fragmentary, as it is associated with molecular and cellular processes on the one hand and with tissue and organ phenotype changes (related to clinical symptoms of disease conditions) on the other. The problem could be solved if we could capture all these fragments of knowledge into predictive models and then compose them into hypermodels that help us tame the complexity that such systemic behavior involves. In 2005 this was simply not possible—the necessary methods and technologies were not available. Now, 10 years later, it seems the right time to reflect on the original vision, the results achieved so far, and what remains to be done." @default.
• W2263185714 created "2016-06-24" @default.
• W2263185714 creator A5064457425 @default.
• W2263185714 creator A5086585880 @default.
• W2263185714 date "2016-07-11" @default.
• W2263185714 modified "2023-10-17" @default.
• W2263185714 title "The Virtual Physiological Human: Ten Years After" @default.
• W2263185714 cites W113246169 @default.
• W2263185714 cites W1498985101 @default.
• W2263185714 cites W1548356335 @default.
• W2263185714 cites W1550726172 @default.
• W2263185714 cites W1581045984 @default.
• W2263185714 cites W1603159750 @default.
• W2263185714 cites W1657403280 @default.
• W2263185714 cites W1936488532 @default.
• W2263185714 cites W1938154233 @default.
• W2263185714 cites W1968092726 @default.
• W2263185714 cites W1969102087 @default.
• W2263185714 cites W1969930741 @default.
• W2263185714 cites W1971722909 @default.
• W2263185714 cites W1974356581 @default.
• W2263185714 cites W1976100126 @default.
• W2263185714 cites W1985940938 @default.
• W2263185714 cites W1989454930 @default.
• W2263185714 cites W1991339919 @default.
• W2263185714 cites W1993294353 @default.
• W2263185714 cites W1999184428 @default.
• W2263185714 cites W1999349277 @default.
• W2263185714 cites W2001089996 @default.
• W2263185714 cites W2001658424 @default.
• W2263185714 cites W2003313420 @default.
• W2263185714 cites W2003762608 @default.
• W2263185714 cites W2009981663 @default.
• W2263185714 cites W2011008525 @default.
• W2263185714 cites W2012566356 @default.
• W2263185714 cites W2015254160 @default.
• W2263185714 cites W2029283050 @default.
• W2263185714 cites W2035778695 @default.
• W2263185714 cites W2039425561 @default.
• W2263185714 cites W2048393236 @default.
• W2263185714 cites W2051953558 @default.
• W2263185714 cites W2053381312 @default.
• W2263185714 cites W2053704132 @default.
• W2263185714 cites W2053912979 @default.
• W2263185714 cites W2055640868 @default.
• W2263185714 cites W2059579312 @default.
• W2263185714 cites W2059681146 @default.
• W2263185714 cites W2069030306 @default.
• W2263185714 cites W2075719804 @default.
• W2263185714 cites W2084443863 @default.
• W2263185714 cites W2084917427 @default.
• W2263185714 cites W2085949935 @default.
• W2263185714 cites W2086334876 @default.
• W2263185714 cites W2087308849 @default.
• W2263185714 cites W2093742839 @default.
• W2263185714 cites W2094308116 @default.
• W2263185714 cites W2095878808 @default.
• W2263185714 cites W2097570569 @default.
• W2263185714 cites W2098065746 @default.
• W2263185714 cites W2101171669 @default.
• W2263185714 cites W2102456200 @default.
• W2263185714 cites W2104081710 @default.
• W2263185714 cites W2106548215 @default.
• W2263185714 cites W2118810625 @default.
• W2263185714 cites W2119535220 @default.
• W2263185714 cites W2119862507 @default.
• W2263185714 cites W2121642757 @default.
• W2263185714 cites W2122242599 @default.
• W2263185714 cites W2123505862 @default.
• W2263185714 cites W2124496721 @default.
• W2263185714 cites W2125220690 @default.
• W2263185714 cites W2125624587 @default.
• W2263185714 cites W2128019672 @default.
• W2263185714 cites W2131176237 @default.
• W2263185714 cites W2131645519 @default.
• W2263185714 cites W2132333593 @default.
• W2263185714 cites W2132961114 @default.
• W2263185714 cites W2133938042 @default.
• W2263185714 cites W2142168519 @default.
• W2263185714 cites W2161629941 @default.
• W2263185714 cites W2161957993 @default.
• W2263185714 cites W2162005259 @default.
• W2263185714 cites W2164184288 @default.
• W2263185714 cites W2164744495 @default.
• W2263185714 cites W2165437542 @default.
• W2263185714 cites W2167160009 @default.
• W2263185714 cites W2169559303 @default.
• W2263185714 cites W2308595026 @default.
• W2263185714 cites W2320707747 @default.
• W2263185714 cites W2488352285 @default.
• W2263185714 cites W288934311 @default.
• W2263185714 cites W42615294 @default.
• W2263185714 cites W73048933 @default.
• W2263185714 cites W89627948 @default.
• W2263185714 doi "https://doi.org/10.1146/annurev-bioeng-110915-114742" @default.
• W2263185714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27420570" @default.
• W2263185714 hasPublicationYear "2016" @default.
• W2263185714 type Work @default.

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