Matches in SemOpenAlex for { <https://semopenalex.org/work/W2263219150> ?p ?o ?g. }
- W2263219150 abstract "Abstract The precancerous lesion known as Barrett’s oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett’s, gastric and oesophageal epithelia that yield divergent tumour types following in vitro transformation and xenografting. Genomic analyses reveal a broad mutational spectrum unique to Barrett’s stem cells that likely reflects their risk for oncogenesis. Remarkably, 25% of cases show no cancer-related genomic changes, suggesting that Barrett’s initiates without driver mutations. Most cases, however, sustain patterns of deletions almost identical to adenocarcinoma though tumour-associated gene amplifications were absent. Notably, those suspected of low-grade dysplasia have p53 mutations or undergo amplifications of proto-oncogenes and receptor tyrosine kinases, implicating these events in lethal transitions. Our findings suggest paths for the initiation and progression of Barrett’s and define a discrete stem cell underlying its regenerative growth whose eradication could prevent oesophageal adenocarcinoma." @default.
- W2263219150 created "2016-06-24" @default.
- W2263219150 creator A5006317716 @default.
- W2263219150 creator A5013888899 @default.
- W2263219150 creator A5019592874 @default.
- W2263219150 creator A5021009003 @default.
- W2263219150 creator A5030323719 @default.
- W2263219150 creator A5035282947 @default.
- W2263219150 creator A5043053884 @default.
- W2263219150 creator A5044234999 @default.
- W2263219150 creator A5049798132 @default.
- W2263219150 creator A5051934593 @default.
- W2263219150 creator A5053444789 @default.
- W2263219150 creator A5055130061 @default.
- W2263219150 creator A5062774997 @default.
- W2263219150 creator A5064144504 @default.
- W2263219150 creator A5064472984 @default.
- W2263219150 creator A5065833999 @default.
- W2263219150 creator A5066748955 @default.
- W2263219150 creator A5068464408 @default.
- W2263219150 creator A5070436450 @default.
- W2263219150 creator A5080847227 @default.
- W2263219150 creator A5088174174 @default.
- W2263219150 date "2016-01-19" @default.
- W2263219150 modified "2023-10-12" @default.
- W2263219150 title "Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion" @default.
- W2263219150 cites W1483496013 @default.
- W2263219150 cites W1500818418 @default.
- W2263219150 cites W1514032394 @default.
- W2263219150 cites W1545398558 @default.
- W2263219150 cites W1910612799 @default.
- W2263219150 cites W1962039696 @default.
- W2263219150 cites W1964807436 @default.
- W2263219150 cites W1968881296 @default.
- W2263219150 cites W1975079377 @default.
- W2263219150 cites W1980740976 @default.
- W2263219150 cites W1984746891 @default.
- W2263219150 cites W1987143624 @default.
- W2263219150 cites W1995491386 @default.
- W2263219150 cites W1997114875 @default.
- W2263219150 cites W1997952452 @default.
- W2263219150 cites W2001010927 @default.
- W2263219150 cites W2001258296 @default.
- W2263219150 cites W2002513358 @default.
- W2263219150 cites W2022293814 @default.
- W2263219150 cites W2026891239 @default.
- W2263219150 cites W2043161346 @default.
- W2263219150 cites W2048143418 @default.
- W2263219150 cites W2049043712 @default.
- W2263219150 cites W2051570610 @default.
- W2263219150 cites W2054451629 @default.
- W2263219150 cites W2055561239 @default.
- W2263219150 cites W2063719489 @default.
- W2263219150 cites W2074478596 @default.
- W2263219150 cites W2075890816 @default.
- W2263219150 cites W2082344079 @default.
- W2263219150 cites W2092654917 @default.
- W2263219150 cites W2103441770 @default.
- W2263219150 cites W2108234281 @default.
- W2263219150 cites W2114023704 @default.
- W2263219150 cites W2114715773 @default.
- W2263219150 cites W2117692326 @default.
- W2263219150 cites W2117981040 @default.
- W2263219150 cites W2119180969 @default.
- W2263219150 cites W2120450267 @default.
- W2263219150 cites W2120636006 @default.
- W2263219150 cites W2125021689 @default.
- W2263219150 cites W2130410032 @default.
- W2263219150 cites W2131738928 @default.
- W2263219150 cites W2140525070 @default.
- W2263219150 cites W2151050386 @default.
- W2263219150 cites W2159059995 @default.
- W2263219150 cites W2159137048 @default.
- W2263219150 cites W2160504871 @default.
- W2263219150 cites W2168544170 @default.
- W2263219150 cites W2404119616 @default.
- W2263219150 cites W4238448376 @default.
- W2263219150 cites W623055175 @default.
- W2263219150 doi "https://doi.org/10.1038/ncomms10380" @default.
- W2263219150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4735693" @default.
- W2263219150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26783136" @default.
- W2263219150 hasPublicationYear "2016" @default.
- W2263219150 type Work @default.
- W2263219150 sameAs 2263219150 @default.
- W2263219150 citedByCount "53" @default.
- W2263219150 countsByYear W22632191502016 @default.
- W2263219150 countsByYear W22632191502017 @default.
- W2263219150 countsByYear W22632191502018 @default.
- W2263219150 countsByYear W22632191502019 @default.
- W2263219150 countsByYear W22632191502020 @default.
- W2263219150 countsByYear W22632191502021 @default.
- W2263219150 countsByYear W22632191502022 @default.
- W2263219150 crossrefType "journal-article" @default.
- W2263219150 hasAuthorship W2263219150A5006317716 @default.
- W2263219150 hasAuthorship W2263219150A5013888899 @default.
- W2263219150 hasAuthorship W2263219150A5019592874 @default.
- W2263219150 hasAuthorship W2263219150A5021009003 @default.
- W2263219150 hasAuthorship W2263219150A5030323719 @default.
- W2263219150 hasAuthorship W2263219150A5035282947 @default.
- W2263219150 hasAuthorship W2263219150A5043053884 @default.