Matches in SemOpenAlex for { <https://semopenalex.org/work/W2263294561> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2263294561 endingPage "187" @default.
- W2263294561 startingPage "181" @default.
- W2263294561 abstract "CYP3A5 gene is located on chromosome 7q21.1 and is responsible for the metabolism of over 50% of all clinically used drugs. 250 breast cancer and same number of healthy age matched controls were analyzed for the polymorphisms of CYP3A5*3 and CYP3A5*6 by polymerase chain reaction-restriction fragment length polymorphism. The normal wild type allele CYP3A5*1 produces correct transcript and individuals with at least one CYP3A5*1 allele can express CYP3A5 at higher levels. In the present study, the frequency of heterozygotes for CYP3A5*1 (1/3) was significantly increased in breast cancer (53.0%) when compared to controls (41.4%) with corresponding increase in CYP3A5*1 allele frequency. The frequency of 3/3 genotype was increased in postmenopausal (40.0%) patients with high BMI, ER, PR and HER2/neu positive status and in housewife group. There was an increase of 1/3 genotype frequency in patients with positive family history and agricultural laborers (55.6%). In conclusion our results suggested that the CYP3A5*3 polymorphism might influence the breast cancer etiology which mainly depends on the type of exposure. CYP3A5*6 allele was not observed in cases as well as in controls." @default.
- W2263294561 created "2016-06-24" @default.
- W2263294561 creator A5000404596 @default.
- W2263294561 creator A5010415280 @default.
- W2263294561 creator A5022795569 @default.
- W2263294561 creator A5031796468 @default.
- W2263294561 creator A5032306935 @default.
- W2263294561 creator A5032433362 @default.
- W2263294561 date "2009-01-01" @default.
- W2263294561 modified "2023-09-23" @default.
- W2263294561 title "Association of CYP3A5*3 and CYP3A5*6 Polymorphisms with Breast Cancer Risk" @default.
- W2263294561 cites W1861305354 @default.
- W2263294561 cites W1968356457 @default.
- W2263294561 cites W1974989528 @default.
- W2263294561 cites W2053813189 @default.
- W2263294561 cites W2058215178 @default.
- W2263294561 cites W2105902511 @default.
- W2263294561 cites W2127736404 @default.
- W2263294561 cites W2144059872 @default.
- W2263294561 cites W2343454638 @default.
- W2263294561 hasPublicationYear "2009" @default.
- W2263294561 type Work @default.
- W2263294561 sameAs 2263294561 @default.
- W2263294561 citedByCount "1" @default.
- W2263294561 countsByYear W22632945612014 @default.
- W2263294561 crossrefType "journal-article" @default.
- W2263294561 hasAuthorship W2263294561A5000404596 @default.
- W2263294561 hasAuthorship W2263294561A5010415280 @default.
- W2263294561 hasAuthorship W2263294561A5022795569 @default.
- W2263294561 hasAuthorship W2263294561A5031796468 @default.
- W2263294561 hasAuthorship W2263294561A5032306935 @default.
- W2263294561 hasAuthorship W2263294561A5032433362 @default.
- W2263294561 hasConcept C104317684 @default.
- W2263294561 hasConcept C121608353 @default.
- W2263294561 hasConcept C126322002 @default.
- W2263294561 hasConcept C134018914 @default.
- W2263294561 hasConcept C135763542 @default.
- W2263294561 hasConcept C143998085 @default.
- W2263294561 hasConcept C146304588 @default.
- W2263294561 hasConcept C149737253 @default.
- W2263294561 hasConcept C180754005 @default.
- W2263294561 hasConcept C37463918 @default.
- W2263294561 hasConcept C530470458 @default.
- W2263294561 hasConcept C54355233 @default.
- W2263294561 hasConcept C71924100 @default.
- W2263294561 hasConcept C86803240 @default.
- W2263294561 hasConcept C90924648 @default.
- W2263294561 hasConcept C92137452 @default.
- W2263294561 hasConceptScore W2263294561C104317684 @default.
- W2263294561 hasConceptScore W2263294561C121608353 @default.
- W2263294561 hasConceptScore W2263294561C126322002 @default.
- W2263294561 hasConceptScore W2263294561C134018914 @default.
- W2263294561 hasConceptScore W2263294561C135763542 @default.
- W2263294561 hasConceptScore W2263294561C143998085 @default.
- W2263294561 hasConceptScore W2263294561C146304588 @default.
- W2263294561 hasConceptScore W2263294561C149737253 @default.
- W2263294561 hasConceptScore W2263294561C180754005 @default.
- W2263294561 hasConceptScore W2263294561C37463918 @default.
- W2263294561 hasConceptScore W2263294561C530470458 @default.
- W2263294561 hasConceptScore W2263294561C54355233 @default.
- W2263294561 hasConceptScore W2263294561C71924100 @default.
- W2263294561 hasConceptScore W2263294561C86803240 @default.
- W2263294561 hasConceptScore W2263294561C90924648 @default.
- W2263294561 hasConceptScore W2263294561C92137452 @default.
- W2263294561 hasIssue "2" @default.
- W2263294561 hasLocation W22632945611 @default.
- W2263294561 hasOpenAccess W2263294561 @default.
- W2263294561 hasPrimaryLocation W22632945611 @default.
- W2263294561 hasRelatedWork W1421017940 @default.
- W2263294561 hasRelatedWork W1925006645 @default.
- W2263294561 hasRelatedWork W2004930472 @default.
- W2263294561 hasRelatedWork W2024870017 @default.
- W2263294561 hasRelatedWork W2040445355 @default.
- W2263294561 hasRelatedWork W2054088252 @default.
- W2263294561 hasRelatedWork W2060864811 @default.
- W2263294561 hasRelatedWork W2091740582 @default.
- W2263294561 hasRelatedWork W2098018778 @default.
- W2263294561 hasRelatedWork W2109965418 @default.
- W2263294561 hasRelatedWork W2115519057 @default.
- W2263294561 hasRelatedWork W2118485566 @default.
- W2263294561 hasRelatedWork W2144988894 @default.
- W2263294561 hasRelatedWork W2167447922 @default.
- W2263294561 hasRelatedWork W2349794901 @default.
- W2263294561 hasRelatedWork W2352563612 @default.
- W2263294561 hasRelatedWork W2363477086 @default.
- W2263294561 hasRelatedWork W2417107783 @default.
- W2263294561 hasRelatedWork W2496973095 @default.
- W2263294561 hasRelatedWork W3205447420 @default.
- W2263294561 hasVolume "3" @default.
- W2263294561 isParatext "false" @default.
- W2263294561 isRetracted "false" @default.
- W2263294561 magId "2263294561" @default.
- W2263294561 workType "article" @default.