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- W2263307921 abstract "Light adaptation in most vertebrates occurs through adjustments in pupil diameter. Teleosts, however, have a fixed pupil size, so they rely on retinomotor movements to regulate the amount of light incident on the photoreceptors. Retinomotor movements include photoreceptor contraction and elongation as well as the aggregation and dispersion of membrane bound pigment granules located in the retinal pigment epithelium. Previous work has shown that pigment granule dispersion can be induced using the neurotransmitter acetylcholine acting via muscarinic receptors and that dispersion can be inhibited by Modd receptor specific antagonists. In this study we demonstrate Modd receptor expression using immunolabeling with an anti M3 antibody and with in situ hybridization using probes that target the M5 receptor. Labeling with the M3 antibody was seen multiple layers of the bluegill retina and was supported by Western blot analysis using bluegill and zebrafish tissue. In situ hybridization of the M5 sequence indicated a similar distribution of the receptor as that seen with the antibody. These results suggest that multiple muscarinic receptor subtypes are expressed in the fish retina, and lay the foundation for future studies to elucidate the role of muscarinic signaling pathways in the retina, especially as they pertain to light adaptation." @default.
- W2263307921 created "2016-06-24" @default.
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- W2263307921 date "2008-03-01" @default.
- W2263307921 modified "2023-10-11" @default.
- W2263307921 title "Expression of Modd muscarinic acetylcholine receptors in the retinas of bluegill and zebra fish" @default.
- W2263307921 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1127.6" @default.
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