Matches in SemOpenAlex for { <https://semopenalex.org/work/W2263313156> ?p ?o ?g. }
- W2263313156 endingPage "273" @default.
- W2263313156 startingPage "255" @default.
- W2263313156 abstract "Progressive multifocal leukoencephalopathy (PML) is a rare but debilitating and frequently fatal viral disease of the central nervous system, primarily affecting individuals with chronically and severely suppressed immune systems. The disease was relatively obscure until the outbreak of HIV/AIDS, when it presented as one of the more frequent opportunistic infections in this immune deficiency syndrome. It attracted additional attention from the medical and scientific community following the discovery of significant PML risk associated with natalizumab, a monoclonal antibody used for treatment of relapsing-remitting multiple sclerosis. This was followed by association of PML with other immunosuppressive or immunomodulating drugs. PML is currently untreatable disease with poor outcomes, so it is a significant concern when developing new immunotherapies. Current prophylaxis and treatment of PML are focused on immune reconstitution, restoration of immune responses to JC virus infection, and eventual suppression of immune reconstitution inflammatory syndrome. This approach was successful in reducing the incidence of PML and improved survival of PML patients with HIV infection. However, the outcome for the majority of PML patients, regardless of their medical history, is still relatively poor. There is a high unmet need for both prophylaxis and treatment of PML. The aim of this review is to discuss potential drug candidates for prophylaxis and treatment of PML with a critical review of previously conducted and completed PML treatment studies as well as to provide perspectives for future therapies." @default.
- W2263313156 created "2016-06-24" @default.
- W2263313156 creator A5008424351 @default.
- W2263313156 creator A5009913955 @default.
- W2263313156 creator A5017487533 @default.
- W2263313156 creator A5058605651 @default.
- W2263313156 creator A5067889391 @default.
- W2263313156 date "2015-09-07" @default.
- W2263313156 modified "2023-09-30" @default.
- W2263313156 title "Progressive multifocal leukoencephalopathy: current treatment options and future perspectives" @default.
- W2263313156 cites W133935704 @default.
- W2263313156 cites W1561755731 @default.
- W2263313156 cites W1566070810 @default.
- W2263313156 cites W1743283402 @default.
- W2263313156 cites W1894906741 @default.
- W2263313156 cites W1906078465 @default.
- W2263313156 cites W1965637547 @default.
- W2263313156 cites W1966118505 @default.
- W2263313156 cites W1967339720 @default.
- W2263313156 cites W1969355897 @default.
- W2263313156 cites W1970244684 @default.
- W2263313156 cites W1972304958 @default.
- W2263313156 cites W1976121808 @default.
- W2263313156 cites W1978238469 @default.
- W2263313156 cites W1986250110 @default.
- W2263313156 cites W1987312812 @default.
- W2263313156 cites W1994844769 @default.
- W2263313156 cites W1995276952 @default.
- W2263313156 cites W1997204666 @default.
- W2263313156 cites W1998110395 @default.
- W2263313156 cites W1998115393 @default.
- W2263313156 cites W2005259841 @default.
- W2263313156 cites W2006427551 @default.
- W2263313156 cites W2010552318 @default.
- W2263313156 cites W2013899237 @default.
- W2263313156 cites W2014789558 @default.
- W2263313156 cites W2028058641 @default.
- W2263313156 cites W2030534917 @default.
- W2263313156 cites W2032103055 @default.
- W2263313156 cites W2033099184 @default.
- W2263313156 cites W2041192078 @default.
- W2263313156 cites W2041786390 @default.
- W2263313156 cites W2042824149 @default.
- W2263313156 cites W2044022462 @default.
- W2263313156 cites W2045992975 @default.
- W2263313156 cites W2048989140 @default.
- W2263313156 cites W2055318935 @default.
- W2263313156 cites W2057649957 @default.
- W2263313156 cites W2057751059 @default.
- W2263313156 cites W2062723067 @default.
- W2263313156 cites W2073551625 @default.
- W2263313156 cites W2079767086 @default.
- W2263313156 cites W2085814875 @default.
- W2263313156 cites W2092350058 @default.
- W2263313156 cites W2093775095 @default.
- W2263313156 cites W2094159877 @default.
- W2263313156 cites W2096638844 @default.
- W2263313156 cites W2100153882 @default.
- W2263313156 cites W2104102900 @default.
- W2263313156 cites W2106804776 @default.
- W2263313156 cites W2108181097 @default.
- W2263313156 cites W2111856386 @default.
- W2263313156 cites W2112742103 @default.
- W2263313156 cites W2114360739 @default.
- W2263313156 cites W2117454445 @default.
- W2263313156 cites W2118794853 @default.
- W2263313156 cites W2120743857 @default.
- W2263313156 cites W2126896396 @default.
- W2263313156 cites W2129626693 @default.
- W2263313156 cites W2132390870 @default.
- W2263313156 cites W2135008723 @default.
- W2263313156 cites W2137017404 @default.
- W2263313156 cites W2139385762 @default.
- W2263313156 cites W2145068137 @default.
- W2263313156 cites W2145556928 @default.
- W2263313156 cites W2146494879 @default.
- W2263313156 cites W2147145007 @default.
- W2263313156 cites W2154425328 @default.
- W2263313156 cites W2155590477 @default.
- W2263313156 cites W2155727138 @default.
- W2263313156 cites W2158096469 @default.
- W2263313156 cites W2162818531 @default.
- W2263313156 cites W2163190122 @default.
- W2263313156 cites W2163962155 @default.
- W2263313156 cites W2164638484 @default.
- W2263313156 cites W2165095500 @default.
- W2263313156 cites W2165229568 @default.
- W2263313156 cites W2166730447 @default.
- W2263313156 cites W2167509616 @default.
- W2263313156 cites W2167964282 @default.
- W2263313156 cites W2169573102 @default.
- W2263313156 cites W2171232241 @default.
- W2263313156 cites W2172275967 @default.
- W2263313156 cites W2186432526 @default.
- W2263313156 cites W2224780480 @default.
- W2263313156 cites W2312792525 @default.
- W2263313156 cites W2318906305 @default.
- W2263313156 cites W2328735339 @default.