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- W2263344215 startingPage "1" @default.
- W2263344215 abstract "Transposons are mobile genetic elements that threaten the survival of species by destabilizing the germline genomes. Limiting the spread of these selfish elements is imperative. Germ cells employ specialized small regulatory RNA pathways to restrain transposon activity. PIWI proteins and Piwi-interacting RNAs (piRNAs) silence transposons at the transcriptional and posttranscriptional level with loss-of-function mutant animals universally exhibiting sterility often associated with germ cell defects. This short review aims to illustrate basic strategies of piRNA-guided defense against transposons. Mechanisms of piRNA silencing are most readily studied in Drosophila melanogaster , which serves as a model to delineate molecular concepts and as a reference for mammalian piRNA systems. PiRNA pathways utilize two major strategies to handle the challenges of transposon control: (1) the hard-wired molecular memory of prior transpositions enables recognition of mobile genetic elements and discriminates transposons from host genes; (2) a feed-forward adaptation mechanism shapes piRNA populations to selectively combat the immediate threat of transposon transcripts. In flies, maternally contributed PIWI-piRNA complexes bolster both of these lines of defense and ensure transgenerational immunity. While recent studies have provided a conceptual framework of what could be viewed as an ancient immune system, we are just beginning to appreciate its many molecular innovations." @default.
- W2263344215 created "2016-06-24" @default.
- W2263344215 creator A5050233692 @default.
- W2263344215 date "2016-01-01" @default.
- W2263344215 modified "2023-10-18" @default.
- W2263344215 title "A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements" @default.
- W2263344215 cites W1426240221 @default.
- W2263344215 cites W1511345757 @default.
- W2263344215 cites W1584433563 @default.
- W2263344215 cites W1596971406 @default.
- W2263344215 cites W1647075334 @default.
- W2263344215 cites W1659482056 @default.
- W2263344215 cites W1823358129 @default.
- W2263344215 cites W1860733958 @default.
- W2263344215 cites W1904094796 @default.
- W2263344215 cites W1952752962 @default.
- W2263344215 cites W1968817160 @default.
- W2263344215 cites W1969865366 @default.
- W2263344215 cites W1971549481 @default.
- W2263344215 cites W1972824210 @default.
- W2263344215 cites W1973596898 @default.
- W2263344215 cites W1974141543 @default.
- W2263344215 cites W1976342457 @default.
- W2263344215 cites W1977733607 @default.
- W2263344215 cites W1979333307 @default.
- W2263344215 cites W1987256197 @default.
- W2263344215 cites W1990654003 @default.
- W2263344215 cites W1991637198 @default.
- W2263344215 cites W1996321460 @default.
- W2263344215 cites W1997270596 @default.
- W2263344215 cites W1997570561 @default.
- W2263344215 cites W1997758697 @default.
- W2263344215 cites W2000210567 @default.
- W2263344215 cites W2004305619 @default.
- W2263344215 cites W2004742914 @default.
- W2263344215 cites W2008276103 @default.
- W2263344215 cites W2009644747 @default.
- W2263344215 cites W2015284016 @default.
- W2263344215 cites W2015402753 @default.
- W2263344215 cites W2019708066 @default.
- W2263344215 cites W2022687771 @default.
- W2263344215 cites W2025419786 @default.
- W2263344215 cites W2026570758 @default.
- W2263344215 cites W2026584449 @default.
- W2263344215 cites W2030071264 @default.
- W2263344215 cites W2030252028 @default.
- W2263344215 cites W2032900712 @default.
- W2263344215 cites W2035260243 @default.
- W2263344215 cites W2035930185 @default.
- W2263344215 cites W2036608178 @default.
- W2263344215 cites W2036963953 @default.
- W2263344215 cites W2036994672 @default.
- W2263344215 cites W2037570580 @default.
- W2263344215 cites W2037948240 @default.
- W2263344215 cites W2039152495 @default.
- W2263344215 cites W2040058302 @default.
- W2263344215 cites W2042086471 @default.
- W2263344215 cites W2043422368 @default.
- W2263344215 cites W2044545834 @default.
- W2263344215 cites W2045991708 @default.
- W2263344215 cites W2046318418 @default.
- W2263344215 cites W2047355421 @default.
- W2263344215 cites W2050021666 @default.
- W2263344215 cites W2050129518 @default.
- W2263344215 cites W2050557699 @default.
- W2263344215 cites W2051275283 @default.
- W2263344215 cites W2051663161 @default.
- W2263344215 cites W2059765085 @default.
- W2263344215 cites W2062288798 @default.
- W2263344215 cites W2062688476 @default.
- W2263344215 cites W2066257084 @default.
- W2263344215 cites W2068056297 @default.
- W2263344215 cites W2068711892 @default.
- W2263344215 cites W2068847708 @default.
- W2263344215 cites W2069011514 @default.
- W2263344215 cites W2071506601 @default.
- W2263344215 cites W2072688582 @default.
- W2263344215 cites W2074106269 @default.
- W2263344215 cites W2077157705 @default.
- W2263344215 cites W2078049816 @default.
- W2263344215 cites W2081028399 @default.
- W2263344215 cites W2081056565 @default.
- W2263344215 cites W2085350682 @default.
- W2263344215 cites W2089053855 @default.
- W2263344215 cites W2089971639 @default.
- W2263344215 cites W2094913043 @default.
- W2263344215 cites W2095198940 @default.
- W2263344215 cites W2095639093 @default.
- W2263344215 cites W2096196036 @default.
- W2263344215 cites W2100050856 @default.
- W2263344215 cites W2101708445 @default.
- W2263344215 cites W2103230738 @default.
- W2263344215 cites W2103852045 @default.
- W2263344215 cites W2104331662 @default.
- W2263344215 cites W2105097906 @default.
- W2263344215 cites W2105202278 @default.
- W2263344215 cites W2106784617 @default.
- W2263344215 cites W2107333779 @default.