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• W2263403818 endingPage "986" @default.
• W2263403818 startingPage "978" @default.
• W2263403818 abstract "Melatonin is an important neuroprotective factor and its receptors are expressed in the fetal brain. During normal pregnancy, maternal melatonin level increases progressively until term and is highly transferred to the fetus, with an important role in brain formation and differentiation. Maternal melatonin provides the first circadian signal to the fetus. This indolamine is also produced de novo and plays a protective role in the human placenta. In pregnancy disorders, both maternal and placental melatonin levels are decreased. Alteration in maternal melatonin level has been associated with disrupted brain programming with long-term effects. Melatonin has strong antioxidant protective effects directly and indirectly via the activation of its receptors. The fetal brain is highly susceptible to oxygenation variation and oxidative stress that can lead to neuronal development disruption. Based on that, several approaches have been tested as a treatment in case of pregnancy disorders and melatonin, through its neuroprotective effect, has been recently accepted against fetal brain injury. This review provides an overview about the protective effects of melatonin during pregnancy and on fetal brain development. Keywords: Placenta, melatonin, preterm birth, neurogenesis disorders, neuroprotection, neural tube, fetus." @default.
• W2263403818 created "2016-06-24" @default.
• W2263403818 creator A5004475432 @default.
• W2263403818 creator A5006658710 @default.
• W2263403818 creator A5011162166 @default.
• W2263403818 creator A5015961969 @default.
• W2263403818 creator A5066205684 @default.
• W2263403818 date "2016-02-15" @default.
• W2263403818 modified "2023-10-16" @default.
• W2263403818 title "Melatonin in Pregnancy: Effects on Brain Development and CNS Programming Disorders" @default.
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