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- W2263443339 abstract "Chronic myelogenous leukemia (CML) usually transforms into accelerated and/or blastic phases (ABP) in 2 to 6 years, and patients with CML often succumb to the disease with cytogenetic evolvement. This 43-year-old man was know for his CML for the last 6 years. He experienced clinical deterioration with massive splenomegaly and granulocytic sarcoma in the enlarged axillary lymph nodes. The white blood cell count was 132.2 x 10{sup 9}/L with 14% basophils and less than 5% myeloblasts in the blood and the marrow. The peripheral blood disclosed 46,XY,t(9;22)(q34;q11)[9]/48,XY,+8,t(9;22)(q34;q11),+22q{sup -}[11]. He was treated accordingly and succumbed to the disease 6 months later. In CML, the Ph{prime}-positive finding is present in about 95% of the patients. The remaining Ph{prime}-negative ones are either bcr-positive or bcr-negative. This group may comprise heterogenous myeloid disorders and shows more often RAS gene mutations than {open_quotes}classic{close_quotes} CML. The common chromosomal abnormalities seen in ABP are an additional Ph{prime} chromosome, trisomy 8, isochrosome 17 and trisomy 19. Some 15-35% of patients in ABP show only Ph{prime} without additional mutation. Although overall survival is grim, patients with CML in ABP with additional chromosomal changes, regardless of the blastic natures, fare worse than those without. The presence of clonal evolution atmore » the onset of ABP denotes clinical and hematologic deterioration and adversely effects patient`s survival.« less" @default.
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- W2263443339 date "1994-09-01" @default.
- W2263443339 modified "2023-09-23" @default.
- W2263443339 title "Clonal evolution in Ph{prime}-positive chronic myelogenous leukemia in blast crisis" @default.
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