FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2263451574> ?p ?o ?g. }

• W2263451574 abstract "BackgroundCurrently evidence regarding influence of the HER tyrosine kinase family - EGFR, HER2, HER3 and HER4 - during disease progression in prostate adenocarcinoma is conflicting – both poor prognosis and no influence on outcome are reported. A small cohort pilot study of paired hormone sensitive (HSPC) and refractory (HRPC) specimens demonstrated HER2/HER4 as positively prognostic in HSPC. Heregulin (HRG), a principle HER family ligand, has previously been noted to have a differential effect on HSPC (decreased proliferation) and HRPC (increased proliferation) cell lines. This study determines influence of HER family and HRG in a larger HSPC cohort and whether influence mechanisms involve proliferation or apoptosis.Patients and MethodsImmunohistochemical staining for HRG, KI67 (proliferation), TUNEL (apoptosis) was performed on pilot study specimens. Further IHC for EGFR, HER2, HER3, HER4, HRG, KI67 and TUNEL was performed on HSPC tissue microarrays. Correlations between target protein expression and the outcomes time to biochemical relapse and overall survival were determined.ResultHigh expression of HER/HRG was correlated with improved prognosis particularly in androgen deprivation treated subcohort (e.g. high EGFR and longer time to relapse p=0.02, high HER2 and delayed relapse p=0.002, high HRG and delayed relapse-p=0.004). High expression of multiple markers increased association significance (e.g. high HER1-4 and delayed relapse p=0.001). No correlations between HER and proliferation or apoptosis were seen.ConclusionThe HER family and HRG are positively prognostic in prostate adenocarcinoma. This has implications for the use of HER family as outcome predictors to guide management." @default.
• W2263451574 created "2016-06-24" @default.
• W2263451574 creator A5049445380 @default.
• W2263451574 date "2008-01-01" @default.
• W2263451574 modified "2023-09-27" @default.
• W2263451574 title "The Role of EGFR, HER 2-4, Heregulin and Downstream Signalling in Prostate Adenocarcinoma" @default.
• W2263451574 cites W145447128 @default.
• W2263451574 cites W1493951453 @default.
• W2263451574 cites W1496143836 @default.
• W2263451574 cites W1511967417 @default.
• W2263451574 cites W1555589113 @default.
• W2263451574 cites W1559303165 @default.
• W2263451574 cites W1563832763 @default.
• W2263451574 cites W1574669021 @default.
• W2263451574 cites W1575945383 @default.
• W2263451574 cites W1579622891 @default.
• W2263451574 cites W1580523172 @default.
• W2263451574 cites W1596047401 @default.
• W2263451574 cites W1599518523 @default.
• W2263451574 cites W1601571585 @default.
• W2263451574 cites W160696900 @default.
• W2263451574 cites W1637461292 @default.
• W2263451574 cites W1644491781 @default.
• W2263451574 cites W1787826185 @default.
• W2263451574 cites W180871936 @default.
• W2263451574 cites W1853804626 @default.
• W2263451574 cites W1867197625 @default.
• W2263451574 cites W19383233 @default.
• W2263451574 cites W1959714734 @default.
• W2263451574 cites W1964321121 @default.
• W2263451574 cites W1965346166 @default.
• W2263451574 cites W1966569638 @default.
• W2263451574 cites W1966823692 @default.
• W2263451574 cites W1967275220 @default.
• W2263451574 cites W1967819851 @default.
• W2263451574 cites W1969022943 @default.
• W2263451574 cites W1969079941 @default.
• W2263451574 cites W1970174108 @default.
• W2263451574 cites W1973033337 @default.
• W2263451574 cites W1973188134 @default.
• W2263451574 cites W1974329776 @default.
• W2263451574 cites W1975705348 @default.
• W2263451574 cites W1976381106 @default.
• W2263451574 cites W1977278230 @default.
• W2263451574 cites W1977818137 @default.
• W2263451574 cites W1984318054 @default.
• W2263451574 cites W1984617792 @default.
• W2263451574 cites W1984754931 @default.
• W2263451574 cites W1985827132 @default.
• W2263451574 cites W1986128826 @default.
• W2263451574 cites W1991448474 @default.
• W2263451574 cites W1991691364 @default.
• W2263451574 cites W1991773279 @default.
• W2263451574 cites W1992785655 @default.
• W2263451574 cites W1996646886 @default.
• W2263451574 cites W1996749803 @default.
• W2263451574 cites W1999802002 @default.
• W2263451574 cites W2001339892 @default.
• W2263451574 cites W2002232322 @default.
• W2263451574 cites W2002502311 @default.
• W2263451574 cites W2003131098 @default.
• W2263451574 cites W2003723677 @default.
• W2263451574 cites W2003852222 @default.
• W2263451574 cites W2003955264 @default.
• W2263451574 cites W2004759810 @default.
• W2263451574 cites W2005658600 @default.
• W2263451574 cites W2006281526 @default.
• W2263451574 cites W2007030561 @default.
• W2263451574 cites W2007256480 @default.
• W2263451574 cites W2007338301 @default.
• W2263451574 cites W2007558014 @default.
• W2263451574 cites W2008498145 @default.
• W2263451574 cites W2008841550 @default.
• W2263451574 cites W2009269691 @default.
• W2263451574 cites W2009280438 @default.
• W2263451574 cites W2010522639 @default.
• W2263451574 cites W2010644263 @default.
• W2263451574 cites W2011455302 @default.
• W2263451574 cites W2012217251 @default.
• W2263451574 cites W2013278694 @default.
• W2263451574 cites W2014111401 @default.
• W2263451574 cites W2014538286 @default.
• W2263451574 cites W2014711201 @default.
• W2263451574 cites W2015675085 @default.
• W2263451574 cites W2016524281 @default.
• W2263451574 cites W2016903147 @default.
• W2263451574 cites W2017362326 @default.
• W2263451574 cites W2020088393 @default.
• W2263451574 cites W2024432096 @default.
• W2263451574 cites W2024763404 @default.
• W2263451574 cites W2025464344 @default.
• W2263451574 cites W2025561101 @default.
• W2263451574 cites W2029849554 @default.
• W2263451574 cites W2030971688 @default.
• W2263451574 cites W2031300004 @default.
• W2263451574 cites W2031687428 @default.
• W2263451574 cites W2031744617 @default.
• W2263451574 cites W2033281378 @default.
• W2263451574 cites W2033764434 @default.
• W2263451574 cites W2033837346 @default.

• next