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• W2263481441 abstract "We have identified several protein-protein interactions amongst the members of the zinc finger, X-linked (ZXD) family of proteins (ZXDA, ZXDB, ZXDC and ZXDC2) that have important roles in the regulation of major histocompatibility complex class II and several myeloid-specific genes. The ZXDC and ZXDA proteins share significant nucleotide sequence homology and each contain ten C2H2 zinc fingers and a transcription activation domain. In addition, ZXDC has a C-terminal region that is necessary to interact with a key cofactor, CIITA (Class II transactivator) and activate Major histocompatibility complex class II and class I (MHC II and MHC I respectively) genes. In chapter II we demonstrate that the ZXDC and ZXDA proteins can selfassociate, as well as, hetero-associate. Moreover, in vitro studies in our lab revealed that the association of ZXDC with ZXDA is necessary and self-association of neither protein was sufficient to interact with CIITA and thereby activate MHC II gene transcription. In addition to CIITA, we found that ZXDC interacted with two other components of the regulatory factor X complex, namely, RFX5 and RFX-ANK (RFX having ankyrin repeats) which are components of the MHC II enhanceosome. The RFX heterotrimeric complex consisting of RFX5, RFX-AP (RFX-associated protein), RFX-ANK binds to the" @default.
• W2263481441 created "2016-06-24" @default.
• W2263481441 creator A5010093229 @default.
• W2263481441 date "2009-01-01" @default.
• W2263481441 modified "2023-09-27" @default.
• W2263481441 title "THE BIOLOGICAL FUNCTION OF INTERACTING PARTNERS OF ZXD FAMILY PROTEINS" @default.
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