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- W2263557584 abstract "Wapl induces cohesin dissociation from DNA throughout the mitotic cell cycle, modulating sister chromatid cohesion and higher-order chromatin structure. Cohesin complexes containing meiosis-specific kleisin subunits govern most aspects of meiotic chromosome function, but whether Wapl regulates these complexes remains unknown. We show that during C. elegans oogenesis WAPL-1 antagonizes binding of cohesin containing COH-3/4 kleisins, but not REC-8, demonstrating that sensitivity to WAPL-1 is dictated by kleisin identity. By restricting the amount of chromosome-associated COH-3/4 cohesin, WAPL-1 controls chromosome structure throughout meiotic prophase. In the absence of REC-8, WAPL-1 inhibits COH-3/4-mediated cohesion, which requires crossover-fated events formed during meiotic recombination. Thus, WAPL-1 promotes functional specialization of meiotic cohesin: WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion. Surprisingly, a WAPL-1-independent mechanism removes cohesin before metaphase I. Our studies provide insight into how meiosis-specific cohesin complexes are regulated to ensure formation of euploid gametes." @default.
- W2263557584 created "2016-06-24" @default.
- W2263557584 creator A5005940091 @default.
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- W2263557584 creator A5081502221 @default.
- W2263557584 creator A5085173519 @default.
- W2263557584 date "2016-02-04" @default.
- W2263557584 modified "2023-09-29" @default.
- W2263557584 title "Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes" @default.
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- W2263557584 doi "https://doi.org/10.7554/elife.10851" @default.
- W2263557584 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4758955" @default.
- W2263557584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26841696" @default.
- W2263557584 hasPublicationYear "2016" @default.
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