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- W2263649084 abstract "Considerable progress has been made in understanding the mechanisms that control the production of specialized neuronal types. However, how the timing of differentiation contributes to neuronal diversity in the developing spinal cord is still a pending question. In this study, we show that CerebroSpinal Fluid-contacting Neurons (CSF-cNs), an anatomically discrete cell type of the ependymal area, originate from surprisingly late neurogenic events in the ventral spinal cord. CSF-cNs are identified by the expression of the transcription factors Gata2 and Gata3, and the ionic channels PKD2L1 and PKD1L2. Contrasting with Gata2/3+ V2b interneurons, CSF-cNs differentiation is independent of Foxn4 and takes place during advanced developmental stages previously assumed to be exclusively gliogenic. CSF-cNs are produced from two distinct dorso-ventral regions of the mouse spinal cord. Most CSF-cNs derive from progenitors circumscribed to the late-p2 and the oligodendrogenic (pOL) domains, whereas a second subset of CSF-cNs arises from cells bordering the floor plate. The development of these two subgroups of CSF-cNs is differentially controlled by Pax6, they adopt separate locations around the postnatal central canal and display electrophysiological differences. Our results highlight that spatio-temporal mechanisms are instrumental in creating neural cell diversity in the ventral spinal cord to produce distinct classes of interneurons, motoneurons, CSF-cNs, glial and ependymal cells." @default.
- W2263649084 created "2016-06-24" @default.
- W2263649084 creator A5017111418 @default.
- W2263649084 creator A5019837733 @default.
- W2263649084 creator A5028435835 @default.
- W2263649084 creator A5034448567 @default.
- W2263649084 creator A5046418169 @default.
- W2263649084 creator A5081110624 @default.
- W2263649084 creator A5085072347 @default.
- W2263649084 date "2016-01-01" @default.
- W2263649084 modified "2023-10-10" @default.
- W2263649084 title "The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord" @default.
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