Matches in SemOpenAlex for { <https://semopenalex.org/work/W2263665557> ?p ?o ?g. }
- W2263665557 endingPage "4252" @default.
- W2263665557 startingPage "4238" @default.
- W2263665557 abstract "Neurite outgrowth is key to the formation of functional circuits during neuronal development. Neurotrophins, including nerve growth factor (NGF), increase neurite outgrowth in part by altering the function and expression of Ca(2+)-permeable cation channels. Here we report that transient receptor potential vanilloid 2 (TRPV2) is an intracellular Ca(2+)-permeable TRPV channel upregulated by NGF via the mitogen-activated protein kinase (MAPK) signaling pathway to augment neurite outgrowth. TRPV2 colocalized with Rab7, a late endosome protein, in addition to TrkA and activated extracellular signal-regulated kinase (ERK) in neurites, indicating that the channel is closely associated with signaling endosomes. In line with these results, we showed that TRPV2 acts as an ERK substrate and identified the motifs necessary for phosphorylation of TRPV2 by ERK. Furthermore, neurite length, TRPV2 expression, and TRPV2-mediated Ca(2+) signals were reduced by mutagenesis of these key ERK phosphorylation sites. Based on these findings, we identified a previously uncharacterized mechanism by which ERK controls TRPV2-mediated Ca(2+) signals in developing neurons and further establish TRPV2 as a critical intracellular ion channel in neuronal function." @default.
- W2263665557 created "2016-06-24" @default.
- W2263665557 creator A5011707402 @default.
- W2263665557 creator A5034760068 @default.
- W2263665557 creator A5035155965 @default.
- W2263665557 creator A5044151777 @default.
- W2263665557 creator A5049422126 @default.
- W2263665557 creator A5060664267 @default.
- W2263665557 creator A5071822488 @default.
- W2263665557 date "2015-12-01" @default.
- W2263665557 modified "2023-10-14" @default.
- W2263665557 title "Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons" @default.
- W2263665557 cites W1495409864 @default.
- W2263665557 cites W1511198581 @default.
- W2263665557 cites W1513561540 @default.
- W2263665557 cites W185056584 @default.
- W2263665557 cites W1963857381 @default.
- W2263665557 cites W1964159573 @default.
- W2263665557 cites W1970587959 @default.
- W2263665557 cites W1970629236 @default.
- W2263665557 cites W1971379872 @default.
- W2263665557 cites W1974107068 @default.
- W2263665557 cites W1974212976 @default.
- W2263665557 cites W1979456903 @default.
- W2263665557 cites W1979803333 @default.
- W2263665557 cites W1982846458 @default.
- W2263665557 cites W1983454594 @default.
- W2263665557 cites W1985501637 @default.
- W2263665557 cites W1988651635 @default.
- W2263665557 cites W1991972386 @default.
- W2263665557 cites W1993871865 @default.
- W2263665557 cites W1994383189 @default.
- W2263665557 cites W1999825570 @default.
- W2263665557 cites W2001734687 @default.
- W2263665557 cites W2003020426 @default.
- W2263665557 cites W2006033801 @default.
- W2263665557 cites W2006132476 @default.
- W2263665557 cites W2012034410 @default.
- W2263665557 cites W2018270283 @default.
- W2263665557 cites W2018411282 @default.
- W2263665557 cites W2019843044 @default.
- W2263665557 cites W2021062479 @default.
- W2263665557 cites W2023947832 @default.
- W2263665557 cites W2024818303 @default.
- W2263665557 cites W2025296977 @default.
- W2263665557 cites W2028489659 @default.
- W2263665557 cites W2032466814 @default.
- W2263665557 cites W2032688072 @default.
- W2263665557 cites W2032993608 @default.
- W2263665557 cites W2033620602 @default.
- W2263665557 cites W2034188706 @default.
- W2263665557 cites W2041502163 @default.
- W2263665557 cites W2041938779 @default.
- W2263665557 cites W2050781058 @default.
- W2263665557 cites W2057041663 @default.
- W2263665557 cites W2057433183 @default.
- W2263665557 cites W2072416078 @default.
- W2263665557 cites W2079061601 @default.
- W2263665557 cites W2080418501 @default.
- W2263665557 cites W2087548571 @default.
- W2263665557 cites W2089922297 @default.
- W2263665557 cites W2091701866 @default.
- W2263665557 cites W2098512086 @default.
- W2263665557 cites W2099686283 @default.
- W2263665557 cites W2112236446 @default.
- W2263665557 cites W2118622904 @default.
- W2263665557 cites W2119934340 @default.
- W2263665557 cites W2123546018 @default.
- W2263665557 cites W2128308759 @default.
- W2263665557 cites W2131545168 @default.
- W2263665557 cites W2138376387 @default.
- W2263665557 cites W2146044794 @default.
- W2263665557 cites W2156231244 @default.
- W2263665557 cites W2159951830 @default.
- W2263665557 cites W2160647546 @default.
- W2263665557 cites W2162208474 @default.
- W2263665557 cites W2167015723 @default.
- W2263665557 cites W2170956454 @default.
- W2263665557 cites W2400228640 @default.
- W2263665557 doi "https://doi.org/10.1128/mcb.00549-15" @default.
- W2263665557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4648816" @default.
- W2263665557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26416880" @default.
- W2263665557 hasPublicationYear "2015" @default.
- W2263665557 type Work @default.
- W2263665557 sameAs 2263665557 @default.
- W2263665557 citedByCount "40" @default.
- W2263665557 countsByYear W22636655572016 @default.
- W2263665557 countsByYear W22636655572017 @default.
- W2263665557 countsByYear W22636655572018 @default.
- W2263665557 countsByYear W22636655572019 @default.
- W2263665557 countsByYear W22636655572020 @default.
- W2263665557 countsByYear W22636655572021 @default.
- W2263665557 countsByYear W22636655572022 @default.
- W2263665557 countsByYear W22636655572023 @default.
- W2263665557 crossrefType "journal-article" @default.
- W2263665557 hasAuthorship W2263665557A5011707402 @default.
- W2263665557 hasAuthorship W2263665557A5034760068 @default.
- W2263665557 hasAuthorship W2263665557A5035155965 @default.