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- W2263773670 abstract "Undesirable changes in lipid metabolism have beenreported among HIV-infected individuals undergoing anti-retroviraltherapy. Considering the peculiarity of pregnant women who are alsofaced with similar metabolic changes, it becomes necessary to ascertainlipid changes that occur in them, and assess the effect of anti-retroviraltherapy (ART), diet and physical exercise on their lipid profile.Methods: The study was conducted in Nnamdi Azikiwe UniversityTeaching Hospital, Nnewi in Anambra State, Nigeria. One hundredsubjects were recruited for this study. This comprised of 50 HIV seropositivepregnant women (test) and 50matched HIV sero-negative,pregnant women (controls) attending ante-natal clinic. Questionnairesand patient records were used to obtain data and information on thesubjects. They were categorized into three groups based on dietaryintake (carbohydrate-rich, protein-rich and cholesterol-rich) and into twogroups based on exposure to physical activity, at least one hour dailyexercising and non-exercising. After an overnight fast, 5mls of blood wascollected from all subjects into plain tubes and sera analyzed for totalcholesterol (TC), triglyceride (TG), low density lipoproteincholesterol(LDL-C) and high density lipoprotein cholesterol (HDL-C)using the VITROS 350 automatic chemistry analyzer.Result: The lipid profile of HIV sero-positive pregnant women weresignificantly lower than in sero-negative pregnant women(p=0.028).There was no statistically significant difference in lipid profilebetween those on ART and those not on ART. With physical exercisedecreased levels of lipids were observed in both test and control groups(p<0.05). There was significant difference in the TC and LDL-C withrespect to the diets for carbohydrate-rich, protein-rich and cholesterolrichdiets (p<0.05) in the control group.Conclusion: Findings from this study suggest that HIV does alter thelipid profile of HIV-infected pregnant women. This, however, causes aderanged lipid profile. Physical activity and diet also play importantroles in the regulation of lipid levels" @default.
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- W2263773670 date "2012-12-01" @default.
- W2263773670 modified "2023-09-23" @default.
- W2263773670 title "Assessment of Lipid Profile in HIV Seropositive Pregnant Women attending Ante-Natal Clinic in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria" @default.
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