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• W2263990211 abstract "•Dynamic epigenetic landscapes contribute to adult tissue plasticity Conrad Waddington’s eponymous 1957 diagram provided a metaphorical framework for considering how sequential developmental fate decisions allow an egg to develop into an embryo. In recent years, the Waddington diagram has been repurposed to illustrate how cellular identity changes in the context of reprogramming. In this Perspective, we revisit the Waddington diagram in light of the emerging recognition that plasticity is part and parcel of adult regeneration. Specifically, we speculate that the “epigenetic landscapes” that define identity in adult tissues are dynamic, facilitating cellular de-differentiation and trans-differentiation in the setting of injury. Conrad Waddington’s eponymous 1957 diagram provided a metaphorical framework for considering how sequential developmental fate decisions allow an egg to develop into an embryo. In recent years, the Waddington diagram has been repurposed to illustrate how cellular identity changes in the context of reprogramming. In this Perspective, we revisit the Waddington diagram in light of the emerging recognition that plasticity is part and parcel of adult regeneration. Specifically, we speculate that the “epigenetic landscapes” that define identity in adult tissues are dynamic, facilitating cellular de-differentiation and trans-differentiation in the setting of injury." @default.
• W2263990211 created "2016-06-24" @default.
• W2263990211 creator A5057187872 @default.
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• W2263990211 date "2016-01-01" @default.
• W2263990211 modified "2023-10-16" @default.
• W2263990211 title "Plasticity in the Adult: How Should the Waddington Diagram Be Applied to Regenerating Tissues?" @default.
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• W2263990211 doi "https://doi.org/10.1016/j.devcel.2015.12.021" @default.
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