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- W2263994477 abstract "This study evaluated as to whether curcumin (CCM) could ameliorate alveolar bone destruction in vivo and dissect its mechanism in vitro. The tartrate-resistant acid phosphatase (TRAP) activity, TRAP staining, quantitative RT-PCR, gelatin zymography, actin-ring formation, and pits formation assay were used to analyse the effect of CCM on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation, activation, and function. Porphyromonas gingivalis LPS- and ligature-induced experimental periodontitis were established to evaluate the therapeutic benefits of CCM in vivo. The results demonstrated that CCM dose dependently diminishes RANKL-induced osteoclast differentiation, and osteoclastic specific genes expression accompanied by a significant attenuation of actin-ring and resorptive pits formation in vitro. Moreover, CCM reduces alveolar bone destruction, decreases TRAP-positive and polymorphonuclear cells infiltration, and suppresses myeloperoxidase activity in vivo. Thus, CCM reduces inflammatory bone loss in vivo by modulating RANKL-mediated osteoclast differentiation, activation, and function." @default.
- W2263994477 created "2016-06-24" @default.
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- W2263994477 date "2016-04-01" @default.
- W2263994477 modified "2023-10-09" @default.
- W2263994477 title "Curcumin ameliorates alveolar bone destruction of experimental periodontitis by modulating osteoclast differentiation, activation and function" @default.
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- W2263994477 doi "https://doi.org/10.1016/j.jff.2016.01.025" @default.
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