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- W2264051447 abstract "The optimization of the two bisphosphonates (disodium pamidronate and zoledronic acid) separation by ion-suppression and ion-pair high-performance liquid chromatography is described. The influence of the eluent pH, composition of the mobile phase and the concentration of complexing ion-pairing agents was investigated. This developed method provides high separation and specificity to bisphosphonate analysis. In quantitative analysis in the optimized conditions (10 mM n-amylamine or n-butylamine; 14% acetonitrile in 0.1 M sodium phosphate buffer, pH=7.0), the method showed good linearity (r=0.9999-0.9998) and suffi- cient sensitivity (10 -7 -10 -8 g/ml). It can be easily and conveniently adopted for the routine quality control analysis." @default.
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- W2264051447 date "2011-09-01" @default.
- W2264051447 modified "2023-09-28" @default.
- W2264051447 title "Determination of Bisphosphonates by Ion-pair HPLC" @default.
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- W2264051447 doi "https://doi.org/10.5109/20311" @default.
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