Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264115105> ?p ?o ?g. }
- W2264115105 abstract "Shigella and Escherichia belong to the Enterobacteriaceae family which are the cause for most of the diarrheal cases in the world. Shigella can cause bacterial dysenteries and shigellosis. One of the most effective proteins for pathogenesis is invasion plasmid antigen C (IpaC). Other bacteria like Enterotoxogenic (ETEC), Enterohemorrhagic (EHEC), and E.coli can also cause diarrhea and produce intestinal disorders. Colonization factor antigen I (CFA/I), a critical virulence protein for these infections, has two subunits i.e. CfaB and CfaE. EHEC Attachment of bacteria is the main step of infection with intimin playing the key role in this function. This study was designed to elicit protection against the majority of diarrheal pathogens via development of polyvalent vaccine against Shigella, ETEC and EHEC. In silico techniques are as best tools to design new vaccines. For this purpose the immunogenic epitopes of CfaB, IpaC and Intimin were identified through bioinformatic tools and were then selected as major antigens to construct a chimeric protein (CII). The humoral and cellular immunities were analyzed bioinformatically. Prediction of allergens and mapping of IgE epitopes were carried out. The bioinformatic analysis showed each domain was folded separately in fusion structure. CII had many T and B cell epitopes in both linear and three-dimensional structures. This prediction of the chimeric construct had the potential to induce CD4+ and CD8+ immune responses against these pathogens. In addition CII could be accessible to surveillance by the immune system in mouse and human. In conclusion, in silico analysis showed that this chimeric protein can be used as a vaccine against Shigella, ETEC and EHEC simultaneously." @default.
- W2264115105 created "2016-06-24" @default.
- W2264115105 creator A5005984345 @default.
- W2264115105 creator A5016961774 @default.
- W2264115105 creator A5044558605 @default.
- W2264115105 creator A5057596333 @default.
- W2264115105 creator A5064617965 @default.
- W2264115105 creator A5090691487 @default.
- W2264115105 date "2013-12-01" @default.
- W2264115105 modified "2023-09-25" @default.
- W2264115105 title "In silico analysis of chimeric recombinant immunogen against three diarrhea causing bacteria" @default.
- W2264115105 cites W1530470635 @default.
- W2264115105 cites W1530886219 @default.
- W2264115105 cites W1536886974 @default.
- W2264115105 cites W1707316173 @default.
- W2264115105 cites W1983882421 @default.
- W2264115105 cites W1991251012 @default.
- W2264115105 cites W1999400290 @default.
- W2264115105 cites W1999563618 @default.
- W2264115105 cites W2009804131 @default.
- W2264115105 cites W2020120939 @default.
- W2264115105 cites W2020564539 @default.
- W2264115105 cites W2026779565 @default.
- W2264115105 cites W2028147409 @default.
- W2264115105 cites W2029653875 @default.
- W2264115105 cites W2041694079 @default.
- W2264115105 cites W2042945312 @default.
- W2264115105 cites W2046230501 @default.
- W2264115105 cites W2060259273 @default.
- W2264115105 cites W2060809301 @default.
- W2264115105 cites W2070091555 @default.
- W2264115105 cites W2086938468 @default.
- W2264115105 cites W2094019736 @default.
- W2264115105 cites W2099514668 @default.
- W2264115105 cites W2102023232 @default.
- W2264115105 cites W2102367710 @default.
- W2264115105 cites W2105422109 @default.
- W2264115105 cites W2108035024 @default.
- W2264115105 cites W2115167726 @default.
- W2264115105 cites W2117666752 @default.
- W2264115105 cites W2119134059 @default.
- W2264115105 cites W2125014261 @default.
- W2264115105 cites W2125699466 @default.
- W2264115105 cites W2127814614 @default.
- W2264115105 cites W2136832355 @default.
- W2264115105 cites W2141157874 @default.
- W2264115105 cites W2142636897 @default.
- W2264115105 cites W2145539071 @default.
- W2264115105 cites W2149984099 @default.
- W2264115105 cites W2150286046 @default.
- W2264115105 cites W2155121556 @default.
- W2264115105 cites W2155201844 @default.
- W2264115105 cites W2156242960 @default.
- W2264115105 cites W2156436400 @default.
- W2264115105 cites W2159767366 @default.
- W2264115105 cites W2160397907 @default.
- W2264115105 cites W2161005920 @default.
- W2264115105 cites W2161257366 @default.
- W2264115105 cites W2165442039 @default.
- W2264115105 cites W2168563654 @default.
- W2264115105 cites W2170543527 @default.
- W2264115105 cites W2171781500 @default.
- W2264115105 cites W2299454160 @default.
- W2264115105 cites W2883755802 @default.
- W2264115105 cites W59606062 @default.
- W2264115105 cites W2001662797 @default.
- W2264115105 cites W2083152645 @default.
- W2264115105 cites W2119566456 @default.
- W2264115105 cites W3168775563 @default.
- W2264115105 doi "https://doi.org/10.22067/jcmr.v5i2.22187" @default.
- W2264115105 hasPublicationYear "2013" @default.
- W2264115105 type Work @default.
- W2264115105 sameAs 2264115105 @default.
- W2264115105 citedByCount "0" @default.
- W2264115105 crossrefType "journal-article" @default.
- W2264115105 hasAuthorship W2264115105A5005984345 @default.
- W2264115105 hasAuthorship W2264115105A5016961774 @default.
- W2264115105 hasAuthorship W2264115105A5044558605 @default.
- W2264115105 hasAuthorship W2264115105A5057596333 @default.
- W2264115105 hasAuthorship W2264115105A5064617965 @default.
- W2264115105 hasAuthorship W2264115105A5090691487 @default.
- W2264115105 hasConcept C104317684 @default.
- W2264115105 hasConcept C118815799 @default.
- W2264115105 hasConcept C123894998 @default.
- W2264115105 hasConcept C147483822 @default.
- W2264115105 hasConcept C159047783 @default.
- W2264115105 hasConcept C159654299 @default.
- W2264115105 hasConcept C179470777 @default.
- W2264115105 hasConcept C195616568 @default.
- W2264115105 hasConcept C203014093 @default.
- W2264115105 hasConcept C2776986154 @default.
- W2264115105 hasConcept C2778910516 @default.
- W2264115105 hasConcept C2779909307 @default.
- W2264115105 hasConcept C2780610775 @default.
- W2264115105 hasConcept C2781152039 @default.
- W2264115105 hasConcept C40767141 @default.
- W2264115105 hasConcept C542903549 @default.
- W2264115105 hasConcept C54355233 @default.
- W2264115105 hasConcept C547475151 @default.
- W2264115105 hasConcept C86803240 @default.