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• W2264142716 abstract "Sleep disordered breathing (SDB) is common in older adults and is strongly associated with cognitive decline, with increasing evidence suggesting that it may represent a risk factor for dementia. Given that SDB is characterized by intermittent episodes of hypoxemia during sleep, it is possible that cognitive impairment may relate to cerebral oxidative stress. This study aimed to examine the relationship between nocturnal markers of hypoxemia and proton magnetic resonance spectroscopy (1H-MRS) markers of oxidative stress within the anterior cingulate cortex (ACC) of the brain. Twenty-four older adults (mean age = 67.9 y) at-risk for dementia were recruited from our Healthy Brain Ageing Research Clinic. At-risk was defined as participants seeking help for assessment and/or intervention for cognitive decline, including those with subjective and/or objective cognitive complaints. This could occur in the context of prior depression or risk factors (e.g., vascular) for dementia. All participants underwent psychiatric, medical and neuropsychological assessment followed by overnight polysomnography. In addition, participants underwent 1H-MRS to derive levels of ACC metabolite glutathione (GSH) reported as a ratio to creatine (GSH/Cr). Increased levels of GSH/Cr were associated with lower oxygen desaturation (r = −0.54, P = 0.007) and more severe apnea-hypopnea index scores during rapid eye movement sleep (r = 0.42, P = 0.050). In addition, ACC GSH/Cr correlated with poorer executive functioning (i.e., response inhibition: r = −0.49, P = 0.015; set shifting: r = −0.43, P = 0.037). Markers of nocturnal hypoxemia and SDB are associated with cerebral oxidative stress in older people at-risk for dementia, suggesting a potential mechanism by which SDB may contribute to brain degeneration, cognitive decline, and dementia. Further work focused on utilizing this biomarker for the early identification and treatment of this possible modifiable risk factor in older persons is now warranted. This study shows for the first time, preliminary in vivo evidence of a possible neurobiological mechanism underpinning the relationship between sleep disordered breathing, cognitive decline and dementia. Specifically, this study demonstrates associations been markers of nocturnal hypoxemia, executive dysfunction and the brain's antioxidant system. From a clinical perspective, the findings of this study further highlight the need for early diagnosis and intervention strategies for sleep disordered breathing in older adults. In addition, further investigations of interventions that directly address oxidative stress are warranted. To facilitate the development of targeted interventions for dementia prevention, future research examining the interrelationship between oxidative stress and cellular processes including inflammation, mitochondrial dysfunction and the deposition of neurofibrillary plaques and tangles are now required." @default.
• W2264142716 created "2016-06-24" @default.
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• W2264142716 date "2016-04-01" @default.
• W2264142716 modified "2023-10-11" @default.
• W2264142716 title "Association of Anterior Cingulate Glutathione with Sleep Apnea in Older Adults At-Risk for Dementia" @default.
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• W2264142716 doi "https://doi.org/10.5665/sleep.5650" @default.
• W2264142716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4791623" @default.
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• W2264142716 hasPublicationYear "2016" @default.
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