Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264151330> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2264151330 abstract "Reactive oxygen species (ROS) is generated due to the influx of oxygen during MI/R and contributes to post-reperfused cardiac contractile dysfunction and increased infarct size. Damaged mitochondria and NADPH oxidase activation are major sites of ROS in MI/R. In prior studies, apo, a NADPH oxidase inhibitor, and mitoQ, a mitochondrial-targeted antioxidant, dose-dependently improved post-reperfused left ventricular developed pressure (LVDP) and reduced infarct size in rat hearts subjected to I(30min)/R(45min). This led us to question whether low doses of apo and mitoQ given together can act synergistically to improve post-reperfused LVDP and reduce infarct size compared to either drug alone or control? Early data shows that the combination of apo (40μM) + mitoQ (1 μM ) (n=7) reduced infarct size to 27 ± 11% compared to mitoQ (1 μM) (n= 6) 54 ± 6% (p<0.05); apo (40 μM) (n=6) 40 ± 8% and control I/R hearts (n=7) 42 ± 5%. Reduced infarct size of the apo + mitoQ combination correlated with an improvement in LVDP (61 ± 4% of baseline) compared to control hearts (44 ± 10% of baseline) and apo 40 μM and mitoQ 1 μM (58 ± 9% and 44 ± 12% of baseline), respectively. Although the combination reduced infarct size and improved post-reperfused LVDP more so then either drug alone or control, at these concentrations the combinations did not act synergistically. Other combinations will be tested to further establish the dose-dependent effects." @default.
- W2264151330 created "2016-06-24" @default.
- W2264151330 creator A5004418458 @default.
- W2264151330 creator A5007579766 @default.
- W2264151330 creator A5039018913 @default.
- W2264151330 creator A5064464123 @default.
- W2264151330 creator A5068290128 @default.
- W2264151330 creator A5079313962 @default.
- W2264151330 creator A5088089771 @default.
- W2264151330 creator A5089321395 @default.
- W2264151330 date "2014-04-01" @default.
- W2264151330 modified "2023-09-24" @default.
- W2264151330 title "Combinational effects of apocynin and mitoquinone in reducing myocardial ischemia/ reperfusion injury (1080.7)" @default.
- W2264151330 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1080.7" @default.
- W2264151330 hasPublicationYear "2014" @default.
- W2264151330 type Work @default.
- W2264151330 sameAs 2264151330 @default.
- W2264151330 citedByCount "0" @default.
- W2264151330 crossrefType "journal-article" @default.
- W2264151330 hasAuthorship W2264151330A5004418458 @default.
- W2264151330 hasAuthorship W2264151330A5007579766 @default.
- W2264151330 hasAuthorship W2264151330A5039018913 @default.
- W2264151330 hasAuthorship W2264151330A5064464123 @default.
- W2264151330 hasAuthorship W2264151330A5068290128 @default.
- W2264151330 hasAuthorship W2264151330A5079313962 @default.
- W2264151330 hasAuthorship W2264151330A5088089771 @default.
- W2264151330 hasAuthorship W2264151330A5089321395 @default.
- W2264151330 hasConcept C126322002 @default.
- W2264151330 hasConcept C164705383 @default.
- W2264151330 hasConcept C185592680 @default.
- W2264151330 hasConcept C2776151105 @default.
- W2264151330 hasConcept C2777209548 @default.
- W2264151330 hasConcept C2779719074 @default.
- W2264151330 hasConcept C2780114680 @default.
- W2264151330 hasConcept C48349386 @default.
- W2264151330 hasConcept C500558357 @default.
- W2264151330 hasConcept C541997718 @default.
- W2264151330 hasConcept C55493867 @default.
- W2264151330 hasConcept C71924100 @default.
- W2264151330 hasConcept C98274493 @default.
- W2264151330 hasConceptScore W2264151330C126322002 @default.
- W2264151330 hasConceptScore W2264151330C164705383 @default.
- W2264151330 hasConceptScore W2264151330C185592680 @default.
- W2264151330 hasConceptScore W2264151330C2776151105 @default.
- W2264151330 hasConceptScore W2264151330C2777209548 @default.
- W2264151330 hasConceptScore W2264151330C2779719074 @default.
- W2264151330 hasConceptScore W2264151330C2780114680 @default.
- W2264151330 hasConceptScore W2264151330C48349386 @default.
- W2264151330 hasConceptScore W2264151330C500558357 @default.
- W2264151330 hasConceptScore W2264151330C541997718 @default.
- W2264151330 hasConceptScore W2264151330C55493867 @default.
- W2264151330 hasConceptScore W2264151330C71924100 @default.
- W2264151330 hasConceptScore W2264151330C98274493 @default.
- W2264151330 hasIssue "S1" @default.
- W2264151330 hasLocation W22641513301 @default.
- W2264151330 hasOpenAccess W2264151330 @default.
- W2264151330 hasPrimaryLocation W22641513301 @default.
- W2264151330 hasRelatedWork W1535385532 @default.
- W2264151330 hasRelatedWork W1586446098 @default.
- W2264151330 hasRelatedWork W2078112726 @default.
- W2264151330 hasRelatedWork W2090071726 @default.
- W2264151330 hasRelatedWork W2111761608 @default.
- W2264151330 hasRelatedWork W2343349662 @default.
- W2264151330 hasRelatedWork W2766815983 @default.
- W2264151330 hasRelatedWork W3030386218 @default.
- W2264151330 hasRelatedWork W3194136768 @default.
- W2264151330 hasRelatedWork W4300799478 @default.
- W2264151330 hasVolume "28" @default.
- W2264151330 isParatext "false" @default.
- W2264151330 isRetracted "false" @default.
- W2264151330 magId "2264151330" @default.
- W2264151330 workType "article" @default.