FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264254939> ?p ?o ?g. }

• W2264254939 endingPage "F221" @default.
• W2264254939 startingPage "F217" @default.
• W2264254939 abstract "Serum FGF23 is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. FGF23 expression is increased by activation of the FGF receptor 1 (FGFR1) in rats with normal renal function and in vitro in bone-derived osteoblast-like cells. We studied the regulation of FGF23 by FGFR1 in vivo in acute and chronic uremia in mice and rats. Folic acid-induced acute kidney injury increased calvaria FGF23 mRNA and serum FGF23 and parathyroid hormone (PTH) levels at 6 h. The FGFR1 receptor inhibitor PD173074 prevented the folic acid-induced increase in both FGF23 mRNA and serum levels but had no effect on serum PTH levels. A more prolonged uremia due to an adenine high-phosphorus diet for 14 days resulted in high levels of FGF23 mRNA and serum FGF23 and PTH. PD173074 decreased serum FGF23 and mRNA levels with no effect on PTH in the adenine high phosphorus-induced uremic rats. Therefore, a derangement in FGF23 regulation starts early in the course of acute kidney injury, is in part independent of the increase in serum PTH, and involves activation of FGFR1. It is possible that FGFR1 in the osteocyte is activated by locally produced canonical FGFs, which are increased in uremia. This is the first demonstration that activation of FGFR1 is essential for the high levels of FGF23 in acute and chronic experimental uremia." @default.
• W2264254939 created "2016-06-24" @default.
• W2264254939 creator A5011199160 @default.
• W2264254939 creator A5027461552 @default.
• W2264254939 creator A5038974400 @default.
• W2264254939 creator A5073940230 @default.
• W2264254939 creator A5076963728 @default.
• W2264254939 date "2016-02-01" @default.
• W2264254939 modified "2023-10-16" @default.
• W2264254939 title "The fibroblast growth factor receptor mediates the increased FGF23 expression in acute and chronic uremia" @default.
• W2264254939 cites W1517070102 @default.
• W2264254939 cites W1997012437 @default.
• W2264254939 cites W2010957958 @default.
• W2264254939 cites W2015668150 @default.
• W2264254939 cites W2017452957 @default.
• W2264254939 cites W2021852822 @default.
• W2264254939 cites W2034451046 @default.
• W2264254939 cites W2035976340 @default.
• W2264254939 cites W2038286433 @default.
• W2264254939 cites W2040329227 @default.
• W2264254939 cites W2041242683 @default.
• W2264254939 cites W2051959338 @default.
• W2264254939 cites W2053152115 @default.
• W2264254939 cites W2060331245 @default.
• W2264254939 cites W2067490907 @default.
• W2264254939 cites W2084180690 @default.
• W2264254939 cites W2099196302 @default.
• W2264254939 cites W2102894828 @default.
• W2264254939 cites W2107420262 @default.
• W2264254939 cites W2127828880 @default.
• W2264254939 cites W2137898353 @default.
• W2264254939 cites W2151412853 @default.
• W2264254939 cites W2152109784 @default.
• W2264254939 cites W2161630557 @default.
• W2264254939 cites W2165912010 @default.
• W2264254939 cites W2168867186 @default.
• W2264254939 cites W2170025614 @default.
• W2264254939 cites W2172119923 @default.
• W2264254939 doi "https://doi.org/10.1152/ajprenal.00332.2015" @default.
• W2264254939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26311115" @default.
• W2264254939 hasPublicationYear "2016" @default.
• W2264254939 type Work @default.
• W2264254939 sameAs 2264254939 @default.
• W2264254939 citedByCount "31" @default.
• W2264254939 countsByYear W22642549392016 @default.
• W2264254939 countsByYear W22642549392017 @default.
• W2264254939 countsByYear W22642549392018 @default.
• W2264254939 countsByYear W22642549392019 @default.
• W2264254939 countsByYear W22642549392020 @default.
• W2264254939 countsByYear W22642549392021 @default.
• W2264254939 countsByYear W22642549392022 @default.
• W2264254939 countsByYear W22642549392023 @default.
• W2264254939 crossrefType "journal-article" @default.
• W2264254939 hasAuthorship W2264254939A5011199160 @default.
• W2264254939 hasAuthorship W2264254939A5027461552 @default.
• W2264254939 hasAuthorship W2264254939A5038974400 @default.
• W2264254939 hasAuthorship W2264254939A5073940230 @default.
• W2264254939 hasAuthorship W2264254939A5076963728 @default.
• W2264254939 hasBestOaLocation W22642549391 @default.
• W2264254939 hasConcept C114276007 @default.
• W2264254939 hasConcept C126322002 @default.
• W2264254939 hasConcept C134018914 @default.
• W2264254939 hasConcept C170493617 @default.
• W2264254939 hasConcept C185592680 @default.
• W2264254939 hasConcept C2776635150 @default.
• W2264254939 hasConcept C2778653478 @default.
• W2264254939 hasConcept C2781208988 @default.
• W2264254939 hasConcept C49418065 @default.
• W2264254939 hasConcept C519063684 @default.
• W2264254939 hasConcept C71924100 @default.
• W2264254939 hasConcept C74373430 @default.
• W2264254939 hasConceptScore W2264254939C114276007 @default.
• W2264254939 hasConceptScore W2264254939C126322002 @default.
• W2264254939 hasConceptScore W2264254939C134018914 @default.
• W2264254939 hasConceptScore W2264254939C170493617 @default.
• W2264254939 hasConceptScore W2264254939C185592680 @default.
• W2264254939 hasConceptScore W2264254939C2776635150 @default.
• W2264254939 hasConceptScore W2264254939C2778653478 @default.
• W2264254939 hasConceptScore W2264254939C2781208988 @default.
• W2264254939 hasConceptScore W2264254939C49418065 @default.
• W2264254939 hasConceptScore W2264254939C519063684 @default.
• W2264254939 hasConceptScore W2264254939C71924100 @default.
• W2264254939 hasConceptScore W2264254939C74373430 @default.
• W2264254939 hasFunder F4320322252 @default.
• W2264254939 hasIssue "3" @default.
• W2264254939 hasLocation W22642549391 @default.
• W2264254939 hasLocation W22642549392 @default.
• W2264254939 hasOpenAccess W2264254939 @default.
• W2264254939 hasPrimaryLocation W22642549391 @default.
• W2264254939 hasRelatedWork W1970114012 @default.
• W2264254939 hasRelatedWork W1972216846 @default.
• W2264254939 hasRelatedWork W2072979799 @default.
• W2264254939 hasRelatedWork W2075043838 @default.
• W2264254939 hasRelatedWork W2131952235 @default.
• W2264254939 hasRelatedWork W222523100 @default.
• W2264254939 hasRelatedWork W2264254939 @default.
• W2264254939 hasRelatedWork W2748952813 @default.
• W2264254939 hasRelatedWork W4205859110 @default.

• next