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- W2264443887 abstract "We have previously shown that phenylephrine(PE)-induced oscillatory Ca2+ signals underlie excitation-contraction coupling in adult rabbit inferior vena cava (IVC). These oscillations are caused by waves of regenerative Ca2+ release, which are maintained by sarcoplasmic reticulum (SR) reloading via junctions formed between plasma membrane and SR (PM-SR). Here we present evidence that these junctions together with oscillatory Ca2+ signaling develop post-natal. We examined the agonist-induced Ca2+ signal in in situ vascular smooth muscle cells (VSMC) of the neonatal rabbit IVC in relation to force generation. PE elicits a biphasic Ca2+ signal with an initial Ca2+ transient followed by a steady state plateau averaging 25 % of the peak value. In contrast to the adult, the plateau phase of PE-induced Ca2+ signal and tonic contraction in the VSMC of neonatal rabbit IVC was abolished by nifedipine. Employing electron microscopy, we found that VSMC in neonatal rabbit IVC posses less junctional SR, 6±1%, as compared with the adult rabbit IVC, 18±1%. Our results suggest that complex structures, defining a nano-domain (~20 nm) and composition, including clusters of Ca2+ and Na+ transport proteins, of the PM-SR junctions develops during the neo-natal period and that this correlates with the appearance of oscillatory Ca2+ signaling in VSMC. This study is supported by funding from the Canadian Institute of Health Research." @default.
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- W2264443887 date "2008-03-01" @default.
- W2264443887 modified "2023-09-23" @default.
- W2264443887 title "Evolution of Ca2+ signals with the development of nano‐domains in smooth muscle cells of the rabbit inferior vena cava" @default.
- W2264443887 doi "https://doi.org/10.1096/fasebj.22.1_supplement.909.8" @default.
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