FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264502258> ?p ?o ?g. }

• W2264502258 endingPage "854" @default.
• W2264502258 startingPage "844" @default.
• W2264502258 abstract "Abstract Tuberous sclerosis (TSC) is a tumor suppressor gene syndrome that is associated with the widespread development of mesenchymal tumor types. Genetically, TSC is said to occur through a classical biallelic inactivation of either TSC genes (TSC1, hamartin or TSC2, tuberin), an event that is implicated in the induction of the mTOR pathway and subsequent tumorigenesis. High Mobility Group A2 (HMGA2), an architectural transcription factor, is known to regulate mesenchymal differentiation and drive mesenchymal tumorigenesis in vivo. Here, we investigated the role of HMGA2 in the pathogenesis of TSC using the TSC2+/− mouse model that similarly mirrors human disease and human tumor samples. We show that HMGA2 expression was detected in 100% of human and mouse TSC tumors and that HMGA2 activation was required for TSC mesenchymal tumorigenesis in genetically engineered mouse models. In contrast to the current dogma, the mTOR pathway was not activated in all TSC2+/− tumors and was elevated in only 50% of human mesenchymal tumors. Moreover, except for a subset of kidney tumors, tuberin was expressed in both human and mouse tumors. Therefore, haploinsufficiency of one TSC tumor suppressor gene was required for tumor initiation, but further tumorigenesis did not require the second hit, as previously postulated. Collectively, these findings demonstrate that tissue-specific genetic mechanisms are employed to promote tumor pathogenesis in TSC and identify a novel, critical pathway for potential therapeutic targeting. Cancer Res; 76(4); 844–54. ©2016 AACR." @default.
• W2264502258 created "2016-06-24" @default.
• W2264502258 creator A5017782179 @default.
• W2264502258 creator A5025979375 @default.
• W2264502258 creator A5039552981 @default.
• W2264502258 creator A5040250816 @default.
• W2264502258 creator A5042744678 @default.
• W2264502258 creator A5068265723 @default.
• W2264502258 date "2016-02-14" @default.
• W2264502258 modified "2023-10-17" @default.
• W2264502258 title "Mesenchymal Tumorigenesis Driven by TSC2 Haploinsufficiency Requires HMGA2 and Is Independent of mTOR Pathway Activation" @default.
• W2264502258 cites W1486174444 @default.
• W2264502258 cites W1535161356 @default.
• W2264502258 cites W1930547966 @default.
• W2264502258 cites W1963672516 @default.
• W2264502258 cites W1971825205 @default.
• W2264502258 cites W1975978177 @default.
• W2264502258 cites W1982992093 @default.
• W2264502258 cites W1995175045 @default.
• W2264502258 cites W1999059827 @default.
• W2264502258 cites W2000343561 @default.
• W2264502258 cites W2007515109 @default.
• W2264502258 cites W2012315992 @default.
• W2264502258 cites W2014162007 @default.
• W2264502258 cites W2014703440 @default.
• W2264502258 cites W2019630675 @default.
• W2264502258 cites W2020084263 @default.
• W2264502258 cites W2029810183 @default.
• W2264502258 cites W2031570078 @default.
• W2264502258 cites W2036965005 @default.
• W2264502258 cites W2041811289 @default.
• W2264502258 cites W2044670696 @default.
• W2264502258 cites W2047256111 @default.
• W2264502258 cites W2060607801 @default.
• W2264502258 cites W2066410429 @default.
• W2264502258 cites W2068466524 @default.
• W2264502258 cites W2071504168 @default.
• W2264502258 cites W2076174029 @default.
• W2264502258 cites W2077858999 @default.
• W2264502258 cites W2081920342 @default.
• W2264502258 cites W2082853003 @default.
• W2264502258 cites W2094622904 @default.
• W2264502258 cites W2099187439 @default.
• W2264502258 cites W2101083009 @default.
• W2264502258 cites W2106990621 @default.
• W2264502258 cites W2112339107 @default.
• W2264502258 cites W2115522932 @default.
• W2264502258 cites W2122205306 @default.
• W2264502258 cites W2125287213 @default.
• W2264502258 cites W2126008912 @default.
• W2264502258 cites W2130937302 @default.
• W2264502258 cites W2136489332 @default.
• W2264502258 cites W2139964260 @default.
• W2264502258 cites W2141362788 @default.
• W2264502258 cites W2144323242 @default.
• W2264502258 cites W2145626364 @default.
• W2264502258 cites W2147028601 @default.
• W2264502258 cites W2148043102 @default.
• W2264502258 cites W2149403980 @default.
• W2264502258 cites W2152973392 @default.
• W2264502258 cites W2153578116 @default.
• W2264502258 cites W2155244534 @default.
• W2264502258 cites W2162324253 @default.
• W2264502258 cites W2168989003 @default.
• W2264502258 cites W2169704588 @default.
• W2264502258 cites W2171722492 @default.
• W2264502258 cites W2171884143 @default.
• W2264502258 cites W2383259826 @default.
• W2264502258 cites W26894586 @default.
• W2264502258 cites W4210953366 @default.
• W2264502258 cites W4238356169 @default.
• W2264502258 doi "https://doi.org/10.1158/0008-5472.can-15-1287" @default.
• W2264502258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5554010" @default.
• W2264502258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26837766" @default.
• W2264502258 hasPublicationYear "2016" @default.
• W2264502258 type Work @default.
• W2264502258 sameAs 2264502258 @default.
• W2264502258 citedByCount "20" @default.
• W2264502258 countsByYear W22645022582016 @default.
• W2264502258 countsByYear W22645022582017 @default.
• W2264502258 countsByYear W22645022582018 @default.
• W2264502258 countsByYear W22645022582019 @default.
• W2264502258 countsByYear W22645022582020 @default.
• W2264502258 countsByYear W22645022582021 @default.
• W2264502258 countsByYear W22645022582022 @default.
• W2264502258 countsByYear W22645022582023 @default.
• W2264502258 crossrefType "journal-article" @default.
• W2264502258 hasAuthorship W2264502258A5017782179 @default.
• W2264502258 hasAuthorship W2264502258A5025979375 @default.
• W2264502258 hasAuthorship W2264502258A5039552981 @default.
• W2264502258 hasAuthorship W2264502258A5040250816 @default.
• W2264502258 hasAuthorship W2264502258A5042744678 @default.
• W2264502258 hasAuthorship W2264502258A5068265723 @default.
• W2264502258 hasBestOaLocation W22645022581 @default.
• W2264502258 hasConcept C104317684 @default.
• W2264502258 hasConcept C127716648 @default.
• W2264502258 hasConcept C145059251 @default.
• W2264502258 hasConcept C198826908 @default.

• next