FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264529781> ?p ?o ?g. }

• W2264529781 endingPage "41" @default.
• W2264529781 startingPage "632" @default.
• W2264529781 abstract "Intravenous infusions of the bradykinin agonist Cereport (labradimil, formerly RMP-7) enhance delivery of concomitantly administered hydrophilic chemotherapeutic agents to solid tumors. The enhanced delivery produces greater in vivo efficacy of chemotherapeutic agents, manifested as suppressed tumor growth and increased survival in tumor-bearing rats. Here we elucidate the mechanisms of action involved with this unique phenomenon, at both the physical and biochemical levels. At the physical level we demonstrate that Cereport modifies the tumor vasculature in several important ways, including transient 1) reductions in interstitial fluid pressure within the tumor, 2) increases in pore size of the vasculature, and 3) increases in total vascular surface area. All three of these changes modify tumor-specific characteristics of the vasculature known to impede drug delivery to the tumor interstitium. Biochemically, we demonstrate that the activation of both of bradykinin's major signaling pathways, the nitric oxide and phospholipase A2/prostaglandin E2 are necessary events. Although pharmacologically blocking either pathway greatly reduced the effects of Cereport, stimulation of either pathway alone did not enhance delivery. However, simultaneous stimulation of both pathways (without exogenous bradykinin B2 receptor stimulation) produced a nearly 2-fold increase in delivery of carboplatin to the tumor. Thus, stimulation of endogenous bradykinin B2 receptors induces at least two parallel biochemical cascades that act synergistically to uniquely modify the tumor vasculature in ways that increase delivery and efficacy of chemotherapeutic agents." @default.
• W2264529781 created "2016-06-24" @default.
• W2264529781 creator A5011313043 @default.
• W2264529781 creator A5030549146 @default.
• W2264529781 creator A5034139513 @default.
• W2264529781 creator A5037743402 @default.
• W2264529781 creator A5051247065 @default.
• W2264529781 creator A5058263241 @default.
• W2264529781 creator A5058329121 @default.
• W2264529781 creator A5061333328 @default.
• W2264529781 creator A5068439776 @default.
• W2264529781 creator A5075004472 @default.
• W2264529781 creator A5080144167 @default.
• W2264529781 creator A5084057364 @default.
• W2264529781 creator A5085057753 @default.
• W2264529781 date "2001-02-01" @default.
• W2264529781 modified "2023-09-23" @default.
• W2264529781 title "Bradykinin modulation of tumor vasculature: II. activation of nitric oxide and phospholipase A2/prostaglandin signaling pathways synergistically modifies vascular physiology and morphology to enhance delivery of chemotherapeutic agents to tumors." @default.
• W2264529781 cites W1937235214 @default.
• W2264529781 cites W1974790579 @default.
• W2264529781 cites W1978321945 @default.
• W2264529781 cites W1990983926 @default.
• W2264529781 cites W1991170847 @default.
• W2264529781 cites W1992689348 @default.
• W2264529781 cites W1993546257 @default.
• W2264529781 cites W2001539595 @default.
• W2264529781 cites W2010967591 @default.
• W2264529781 cites W2022784058 @default.
• W2264529781 cites W2023027189 @default.
• W2264529781 cites W2026331267 @default.
• W2264529781 cites W2046057016 @default.
• W2264529781 cites W2074766850 @default.
• W2264529781 cites W2092664299 @default.
• W2264529781 cites W2109101802 @default.
• W2264529781 cites W2117013761 @default.
• W2264529781 cites W2121966925 @default.
• W2264529781 cites W2130381329 @default.
• W2264529781 cites W2135777634 @default.
• W2264529781 cites W2141394481 @default.
• W2264529781 cites W2159943778 @default.
• W2264529781 cites W2169142949 @default.
• W2264529781 cites W2255406689 @default.
• W2264529781 cites W34237247 @default.
• W2264529781 cites W612079814 @default.
• W2264529781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11160652" @default.
• W2264529781 hasPublicationYear "2001" @default.
• W2264529781 type Work @default.
• W2264529781 sameAs 2264529781 @default.
• W2264529781 citedByCount "14" @default.
• W2264529781 countsByYear W22645297812012 @default.
• W2264529781 countsByYear W22645297812016 @default.
• W2264529781 countsByYear W22645297812017 @default.
• W2264529781 countsByYear W22645297812018 @default.
• W2264529781 countsByYear W22645297812022 @default.
• W2264529781 crossrefType "journal-article" @default.
• W2264529781 hasAuthorship W2264529781A5011313043 @default.
• W2264529781 hasAuthorship W2264529781A5030549146 @default.
• W2264529781 hasAuthorship W2264529781A5034139513 @default.
• W2264529781 hasAuthorship W2264529781A5037743402 @default.
• W2264529781 hasAuthorship W2264529781A5051247065 @default.
• W2264529781 hasAuthorship W2264529781A5058263241 @default.
• W2264529781 hasAuthorship W2264529781A5058329121 @default.
• W2264529781 hasAuthorship W2264529781A5061333328 @default.
• W2264529781 hasAuthorship W2264529781A5068439776 @default.
• W2264529781 hasAuthorship W2264529781A5075004472 @default.
• W2264529781 hasAuthorship W2264529781A5080144167 @default.
• W2264529781 hasAuthorship W2264529781A5084057364 @default.
• W2264529781 hasAuthorship W2264529781A5085057753 @default.
• W2264529781 hasConcept C134018914 @default.
• W2264529781 hasConcept C150903083 @default.
• W2264529781 hasConcept C153939273 @default.
• W2264529781 hasConcept C170493617 @default.
• W2264529781 hasConcept C185592680 @default.
• W2264529781 hasConcept C207001950 @default.
• W2264529781 hasConcept C24998067 @default.
• W2264529781 hasConcept C2779591629 @default.
• W2264529781 hasConcept C2780664492 @default.
• W2264529781 hasConcept C502942594 @default.
• W2264529781 hasConcept C519581460 @default.
• W2264529781 hasConcept C55493867 @default.
• W2264529781 hasConcept C71924100 @default.
• W2264529781 hasConcept C86803240 @default.
• W2264529781 hasConcept C98274493 @default.
• W2264529781 hasConceptScore W2264529781C134018914 @default.
• W2264529781 hasConceptScore W2264529781C150903083 @default.
• W2264529781 hasConceptScore W2264529781C153939273 @default.
• W2264529781 hasConceptScore W2264529781C170493617 @default.
• W2264529781 hasConceptScore W2264529781C185592680 @default.
• W2264529781 hasConceptScore W2264529781C207001950 @default.
• W2264529781 hasConceptScore W2264529781C24998067 @default.
• W2264529781 hasConceptScore W2264529781C2779591629 @default.
• W2264529781 hasConceptScore W2264529781C2780664492 @default.
• W2264529781 hasConceptScore W2264529781C502942594 @default.
• W2264529781 hasConceptScore W2264529781C519581460 @default.
• W2264529781 hasConceptScore W2264529781C55493867 @default.
• W2264529781 hasConceptScore W2264529781C71924100 @default.
• W2264529781 hasConceptScore W2264529781C86803240 @default.
• W2264529781 hasConceptScore W2264529781C98274493 @default.

• next