Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264549039> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2264549039 endingPage "7" @default.
- W2264549039 startingPage "3" @default.
- W2264549039 abstract "Defective regulation of apoptosis may play a role in the development of autoimmune diseases, and the proto-oncogene bcl-2 is known to inhibit cells from undergoing apoptosis. We studied the rate of apoptosis with the expression of bcl-2 in peripheral blood lymphocytes of patients with systemic lupus erythematosus (SLE). A lower proportion of lymphocytes were bcl-2+ in SLE patients with active disease (median 84.9%) than in patients with inactive disease or normal (medians 95.3% and 97.1% respectively, p < 0.05). The rate of apoptosis of freshly isolated PBL was significantly higher in SLE patients than in normal (medians 1.2% vs 0.5%, p < 0.05). After 48-hour culture the apoptotic rate was further increased in SLE patients, particularly those with active disease (SLE overall 34.2%, active 62% inactive 27.5%, normal 11.25%). These findings support the theory that in SLE patients increased apoptosis may provide a source of extracellular nuclear antigens which stimulate the autoimmune response and form immune complexes with autoantibodies." @default.
- W2264549039 created "2016-06-24" @default.
- W2264549039 creator A5004488408 @default.
- W2264549039 creator A5013801560 @default.
- W2264549039 creator A5081427824 @default.
- W2264549039 date "1997-03-01" @default.
- W2264549039 modified "2023-10-01" @default.
- W2264549039 title "Increased rate of apoptosis and decreased expression of bcl-2 protein in peripheral blood lymphocytes from patients with active systemic lupus erythematosus." @default.
- W2264549039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9251841" @default.
- W2264549039 hasPublicationYear "1997" @default.
- W2264549039 type Work @default.
- W2264549039 sameAs 2264549039 @default.
- W2264549039 citedByCount "5" @default.
- W2264549039 countsByYear W22645490392015 @default.
- W2264549039 countsByYear W22645490392019 @default.
- W2264549039 crossrefType "journal-article" @default.
- W2264549039 hasAuthorship W2264549039A5004488408 @default.
- W2264549039 hasAuthorship W2264549039A5013801560 @default.
- W2264549039 hasAuthorship W2264549039A5081427824 @default.
- W2264549039 hasConcept C126322002 @default.
- W2264549039 hasConcept C134018914 @default.
- W2264549039 hasConcept C147483822 @default.
- W2264549039 hasConcept C159654299 @default.
- W2264549039 hasConcept C163764329 @default.
- W2264549039 hasConcept C190283241 @default.
- W2264549039 hasConcept C203014093 @default.
- W2264549039 hasConcept C2775915377 @default.
- W2264549039 hasConcept C2776912625 @default.
- W2264549039 hasConcept C2779075594 @default.
- W2264549039 hasConcept C2779134260 @default.
- W2264549039 hasConcept C28406088 @default.
- W2264549039 hasConcept C3017910909 @default.
- W2264549039 hasConcept C55493867 @default.
- W2264549039 hasConcept C71924100 @default.
- W2264549039 hasConcept C86803240 @default.
- W2264549039 hasConcept C8891405 @default.
- W2264549039 hasConcept C95444343 @default.
- W2264549039 hasConceptScore W2264549039C126322002 @default.
- W2264549039 hasConceptScore W2264549039C134018914 @default.
- W2264549039 hasConceptScore W2264549039C147483822 @default.
- W2264549039 hasConceptScore W2264549039C159654299 @default.
- W2264549039 hasConceptScore W2264549039C163764329 @default.
- W2264549039 hasConceptScore W2264549039C190283241 @default.
- W2264549039 hasConceptScore W2264549039C203014093 @default.
- W2264549039 hasConceptScore W2264549039C2775915377 @default.
- W2264549039 hasConceptScore W2264549039C2776912625 @default.
- W2264549039 hasConceptScore W2264549039C2779075594 @default.
- W2264549039 hasConceptScore W2264549039C2779134260 @default.
- W2264549039 hasConceptScore W2264549039C28406088 @default.
- W2264549039 hasConceptScore W2264549039C3017910909 @default.
- W2264549039 hasConceptScore W2264549039C55493867 @default.
- W2264549039 hasConceptScore W2264549039C71924100 @default.
- W2264549039 hasConceptScore W2264549039C86803240 @default.
- W2264549039 hasConceptScore W2264549039C8891405 @default.
- W2264549039 hasConceptScore W2264549039C95444343 @default.
- W2264549039 hasIssue "1" @default.
- W2264549039 hasLocation W22645490391 @default.
- W2264549039 hasOpenAccess W2264549039 @default.
- W2264549039 hasPrimaryLocation W22645490391 @default.
- W2264549039 hasRelatedWork W1977810547 @default.
- W2264549039 hasRelatedWork W1994357700 @default.
- W2264549039 hasRelatedWork W1995637265 @default.
- W2264549039 hasRelatedWork W2016318369 @default.
- W2264549039 hasRelatedWork W2115551679 @default.
- W2264549039 hasRelatedWork W2264549039 @default.
- W2264549039 hasRelatedWork W2990071069 @default.
- W2264549039 hasRelatedWork W2999585816 @default.
- W2264549039 hasRelatedWork W3150026412 @default.
- W2264549039 hasRelatedWork W3173336521 @default.
- W2264549039 hasVolume "15" @default.
- W2264549039 isParatext "false" @default.
- W2264549039 isRetracted "false" @default.
- W2264549039 magId "2264549039" @default.
- W2264549039 workType "article" @default.