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• W2264585211 abstract "Alexander Gusev, Bogdan Pasaniuc and colleagues present a strategy that integrates gene expression measurements with summary statistics from large-scale genome-wide association studies to identify genes whose cis-regulated expression is associated with complex traits. They identify 69 new genes significantly associated with obesity-related traits and illustrate how this approach can provide insights into the genetic basis of complex traits. Many genetic variants influence complex traits by modulating gene expression, thus altering the abundance of one or multiple proteins. Here we introduce a powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits. We leverage expression imputation from genetic data to perform a transcriptome-wide association study (TWAS) to identify significant expression-trait associations. We applied our approaches to expression data from blood and adipose tissue measured in ∼3,000 individuals overall. We imputed gene expression into GWAS data from over 900,000 phenotype measurements to identify 69 new genes significantly associated with obesity-related traits (BMI, lipids and height). Many of these genes are associated with relevant phenotypes in the Hybrid Mouse Diversity Panel. Our results showcase the power of integrating genotype, gene expression and phenotype to gain insights into the genetic basis of complex traits." @default.
• W2264585211 created "2016-06-24" @default.
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• W2264585211 date "2016-02-08" @default.
• W2264585211 modified "2023-10-18" @default.
• W2264585211 title "Integrative approaches for large-scale transcriptome-wide association studies" @default.
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• W2264585211 doi "https://doi.org/10.1038/ng.3506" @default.
• W2264585211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4767558" @default.
• W2264585211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26854917" @default.
• W2264585211 hasPublicationYear "2016" @default.
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