FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264651662> ?p ?o ?g. }

• W2264651662 endingPage "5689" @default.
• W2264651662 startingPage "5677" @default.
• W2264651662 abstract "// Honghe Wang 1 , Wei Liu 2 , ShaNekkia Black 1 , Omari Turner 1 , Juliet M. Daniel 5 , Windy Dean-Colomb 6 , Qinghua P. He 3 , Melissa Davis 4 , Clayton Yates 1 1 Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL, USA 2 Laboratory of Comparative Carcinogenesis, Cancer Center of Research, Frederick, MD, USA 3 Department of Chemical Engineering, Tuskegee University, Tuskegee, AL, USA 4 Department of Genetics, University of Georgia, Athens, GA, USA 5 Department of Biology, McMaster University, Hamilton, ON, Canada 6 Department of Oncologic Research, University Hospital and Clinics, Lafayette General Health, Lafayette, LA, USA Correspondence to: Clayton Yates, e-mail: cyates@mytu.tuskegee.edu Keywords: miRNA, Kaiso, DNA methylation, prostate cancer Received: July 10, 2015      Accepted: December 09, 2015      Published: December 30, 2015 ABSTRACT Kaiso, a member of the BTB/POZ zinc finger protein family, functions as a transcriptional repressor by binding to sequence-specific Kaiso binding sites or to methyl-CpG dinucleotides. Previously, we demonstrated that Kaiso overexpression and nuclear localization correlated with the progression of prostate cancer (PCa). Therefore, our objective was to explore the molecular mechanisms underlying Kaiso-mediated PCa progression. Comparative analysis of miRNA arrays revealed that 13 miRNAs were significantly altered (> 1.5 fold, p < 0.05) in sh-Kaiso PC-3 compared to sh-Scr control cells. Real-time PCR validated that three miRNAs (9, 31, 636) were increased in sh-Kaiso cells similar to cells treated with 5-aza-2′-deoxycytidine. miR-31 expression negatively correlated with Kaiso expression and with methylation of the miR-31 promoter in a panel of PCa cell lines. ChIP assays revealed that Kaiso binds directly to the miR-31 promoter in a methylation-dependent manner. Over-expression of miR-31 decreased cell proliferation, migration and invasiveness of PC-3 cells, whereas cells transfected with anti-miR-31 restored proliferation, migration and invasiveness of sh-Kaiso PC-3 cells. In PCa patients, Kaiso high/miR-31 low expression correlated with worse overall survival relative to each marker individually. In conclusion, these results demonstrate that Kaiso promotes cell migration and invasiveness through regulation of miR-31 expression." @default.
• W2264651662 created "2016-06-24" @default.
• W2264651662 creator A5006296731 @default.
• W2264651662 creator A5042867829 @default.
• W2264651662 creator A5050980626 @default.
• W2264651662 creator A5055507874 @default.
• W2264651662 creator A5056512044 @default.
• W2264651662 creator A5060515951 @default.
• W2264651662 creator A5061000332 @default.
• W2264651662 creator A5071037763 @default.
• W2264651662 creator A5071666554 @default.
• W2264651662 date "2015-12-30" @default.
• W2264651662 modified "2023-10-10" @default.
• W2264651662 title "Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression" @default.
• W2264651662 cites W1856564249 @default.
• W2264651662 cites W1858107219 @default.
• W2264651662 cites W1951809136 @default.
• W2264651662 cites W1968183043 @default.
• W2264651662 cites W1969133654 @default.
• W2264651662 cites W1978944350 @default.
• W2264651662 cites W1982814339 @default.
• W2264651662 cites W1983453097 @default.
• W2264651662 cites W1984869669 @default.
• W2264651662 cites W1988927152 @default.
• W2264651662 cites W2004699369 @default.
• W2264651662 cites W2006023010 @default.
• W2264651662 cites W2010917712 @default.
• W2264651662 cites W2017905687 @default.
• W2264651662 cites W2020170641 @default.
• W2264651662 cites W2034191509 @default.
• W2264651662 cites W2036982851 @default.
• W2264651662 cites W2048516127 @default.
• W2264651662 cites W2053421436 @default.
• W2264651662 cites W2070765029 @default.
• W2264651662 cites W2088623634 @default.
• W2264651662 cites W2089255658 @default.
• W2264651662 cites W2090023298 @default.
• W2264651662 cites W2098422521 @default.
• W2264651662 cites W2099275419 @default.
• W2264651662 cites W2112581947 @default.
• W2264651662 cites W2113345521 @default.
• W2264651662 cites W2116507825 @default.
• W2264651662 cites W2126315841 @default.
• W2264651662 cites W2129708956 @default.
• W2264651662 cites W2134548024 @default.
• W2264651662 cites W2152326032 @default.
• W2264651662 cites W2156843318 @default.
• W2264651662 cites W2158944729 @default.
• W2264651662 cites W2159049774 @default.
• W2264651662 cites W2159575889 @default.
• W2264651662 cites W2163311832 @default.
• W2264651662 cites W2171605654 @default.
• W2264651662 doi "https://doi.org/10.18632/oncotarget.6801" @default.
• W2264651662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4868713" @default.
• W2264651662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26734997" @default.
• W2264651662 hasPublicationYear "2015" @default.
• W2264651662 type Work @default.
• W2264651662 sameAs 2264651662 @default.
• W2264651662 citedByCount "39" @default.
• W2264651662 countsByYear W22646516622016 @default.
• W2264651662 countsByYear W22646516622017 @default.
• W2264651662 countsByYear W22646516622018 @default.
• W2264651662 countsByYear W22646516622019 @default.
• W2264651662 countsByYear W22646516622020 @default.
• W2264651662 countsByYear W22646516622021 @default.
• W2264651662 countsByYear W22646516622022 @default.
• W2264651662 countsByYear W22646516622023 @default.
• W2264651662 crossrefType "journal-article" @default.
• W2264651662 hasAuthorship W2264651662A5006296731 @default.
• W2264651662 hasAuthorship W2264651662A5042867829 @default.
• W2264651662 hasAuthorship W2264651662A5050980626 @default.
• W2264651662 hasAuthorship W2264651662A5055507874 @default.
• W2264651662 hasAuthorship W2264651662A5056512044 @default.
• W2264651662 hasAuthorship W2264651662A5060515951 @default.
• W2264651662 hasAuthorship W2264651662A5061000332 @default.
• W2264651662 hasAuthorship W2264651662A5071037763 @default.
• W2264651662 hasAuthorship W2264651662A5071666554 @default.
• W2264651662 hasBestOaLocation W22646516621 @default.
• W2264651662 hasConcept C104317684 @default.
• W2264651662 hasConcept C121608353 @default.
• W2264651662 hasConcept C126322002 @default.
• W2264651662 hasConcept C145059251 @default.
• W2264651662 hasConcept C150194340 @default.
• W2264651662 hasConcept C190727270 @default.
• W2264651662 hasConcept C2780192828 @default.
• W2264651662 hasConcept C41091548 @default.
• W2264651662 hasConcept C502942594 @default.
• W2264651662 hasConcept C54355233 @default.
• W2264651662 hasConcept C555283112 @default.
• W2264651662 hasConcept C71924100 @default.
• W2264651662 hasConcept C86803240 @default.
• W2264651662 hasConceptScore W2264651662C104317684 @default.
• W2264651662 hasConceptScore W2264651662C121608353 @default.
• W2264651662 hasConceptScore W2264651662C126322002 @default.
• W2264651662 hasConceptScore W2264651662C145059251 @default.
• W2264651662 hasConceptScore W2264651662C150194340 @default.
• W2264651662 hasConceptScore W2264651662C190727270 @default.
• W2264651662 hasConceptScore W2264651662C2780192828 @default.

• next