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• W2264672021 abstract "Efforts to find a cure for type 1 diabetes have focused on the removal of the autoimmune pathophysiologic substrate, with the use of immunosuppressive regimens including autologous hematopoietic stem cell transplantation (AHSCT). The main objective of determining long-term insulin independence as well as changes in glycated hemoglobin (HbA1c). Secondary outcomes were procedure morbidity and the need for hospital management. We enrolled patients with type 1 diabetes between 2012 and 2014. Median follow-up was 34 months (range, 25–56 mo). Ambulatory care. We decided to carry out an AHSCT protocol using a less toxic and affordable simplified method based on fludarabine in an outpatient setting. Patients were of both sexes, age 8–25 years, with positive levels of anti-GAD antibodies, a C-peptide level >1.0 ng/mL, and <3 months since diagnosis. Insulin independence. Sixteen patients were included. Overall response was 81% with seven patients achieving insulin independence (44%); six were partial responders (37%) whereas three were nonresponders (19%). The HbA1c level showed a mean decrease of −2.3% at 6 months in the Insulin Independence group. Median age was 12 years old (range, 8–17 years old). A mean of 11.5 × 106 CD34+ cells (SD ± 8.2) was obtained. Related mortality at 100 days was 0% as well as during follow-up. Outpatient setting was 100%. Simplified AHSCT in an outpatient setting is a feasible, safe and potentially therapeutic intervention for early-onset type 1 diabetes." @default.
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• W2264672021 date "2016-05-01" @default.
• W2264672021 modified "2023-10-18" @default.
• W2264672021 title "Long-Term Insulin Independence in Type 1 Diabetes Mellitus Using a Simplified Autologous Stem Cell Transplant" @default.
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• W2264672021 doi "https://doi.org/10.1210/jc.2015-2776" @default.
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