Matches in SemOpenAlex for { <https://semopenalex.org/work/W2264708629> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W2264708629 endingPage "804" @default.
- W2264708629 startingPage "796" @default.
- W2264708629 abstract "We demonstrated previously that acetylcholine (ACh) induces Ca++ oscillations in tracheal myocytes. These oscillations, as measured with fluo3-loaded cells and confocal microfluorimetry, correlated with Ca++-dependent Cl- current (Clca) oscillations measured by whole-cell voltage-clamp recording. In the current study, we investigated the role of inositol 1,4,5-trisphosphate (IP3) in ACh-induced oscillations in Ca++ and membrane currents. Both an IP3 receptor monoclonal antibody (5 micrograms/ml) and an IP3 receptor antagonist, heparin (5 mg/ml), directly introduced into the cells via the patch pipette, reduced or abolished oscillations in Clca induced by ACh. In addition, IP3 (1-100 microM) applied intracellularly, elicited concentration-dependent Clca oscillations that resembled those induced by ACh. Increasing external Ca++ concentration enhanced IP3-induced Clca oscillations, whereas verapamil (10 microM), a voltage-operated Ca++ channel blocker, attenuated IP3-induced Clca oscillations as well as both control and IP3-enhanced spontaneous transient outward currents. However, neither 5 microgram/ml IP3 receptor monoclonal antibody nor 5 mg/ml heparin altered the caffeine-induced transient Clca. Caffeine (10 mM) reversibly eliminated IP3-induced Clca oscillations as well as IP3-enhanced spontaneous transient outward currents, which indicates that caffeine releases Ca++ via a mechanism independent of the IP3 receptor. The findings are consistent with the hypothesis that ACh-induced Ca++ oscillations can arise and be sustained via IP3-induced Ca++ release pathways." @default.
- W2264708629 created "2016-06-24" @default.
- W2264708629 creator A5015777285 @default.
- W2264708629 creator A5059504448 @default.
- W2264708629 date "1996-05-01" @default.
- W2264708629 modified "2023-09-23" @default.
- W2264708629 title "Acetylcholine-induced Ca++-dependent chloride current oscillations are mediated by inositol 1,4,5-trisphosphate in tracheal myocytes." @default.
- W2264708629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8627561" @default.
- W2264708629 hasPublicationYear "1996" @default.
- W2264708629 type Work @default.
- W2264708629 sameAs 2264708629 @default.
- W2264708629 citedByCount "13" @default.
- W2264708629 countsByYear W22647086292015 @default.
- W2264708629 countsByYear W22647086292019 @default.
- W2264708629 crossrefType "journal-article" @default.
- W2264708629 hasAuthorship W2264708629A5015777285 @default.
- W2264708629 hasAuthorship W2264708629A5059504448 @default.
- W2264708629 hasConcept C113217602 @default.
- W2264708629 hasConcept C12554922 @default.
- W2264708629 hasConcept C134018914 @default.
- W2264708629 hasConcept C145822097 @default.
- W2264708629 hasConcept C147944092 @default.
- W2264708629 hasConcept C152624196 @default.
- W2264708629 hasConcept C170493617 @default.
- W2264708629 hasConcept C185592680 @default.
- W2264708629 hasConcept C207200792 @default.
- W2264708629 hasConcept C2775910092 @default.
- W2264708629 hasConcept C2777427919 @default.
- W2264708629 hasConcept C55493867 @default.
- W2264708629 hasConcept C86803240 @default.
- W2264708629 hasConceptScore W2264708629C113217602 @default.
- W2264708629 hasConceptScore W2264708629C12554922 @default.
- W2264708629 hasConceptScore W2264708629C134018914 @default.
- W2264708629 hasConceptScore W2264708629C145822097 @default.
- W2264708629 hasConceptScore W2264708629C147944092 @default.
- W2264708629 hasConceptScore W2264708629C152624196 @default.
- W2264708629 hasConceptScore W2264708629C170493617 @default.
- W2264708629 hasConceptScore W2264708629C185592680 @default.
- W2264708629 hasConceptScore W2264708629C207200792 @default.
- W2264708629 hasConceptScore W2264708629C2775910092 @default.
- W2264708629 hasConceptScore W2264708629C2777427919 @default.
- W2264708629 hasConceptScore W2264708629C55493867 @default.
- W2264708629 hasConceptScore W2264708629C86803240 @default.
- W2264708629 hasIssue "2" @default.
- W2264708629 hasLocation W22647086291 @default.
- W2264708629 hasOpenAccess W2264708629 @default.
- W2264708629 hasPrimaryLocation W22647086291 @default.
- W2264708629 hasRelatedWork W123996843 @default.
- W2264708629 hasRelatedWork W1522274820 @default.
- W2264708629 hasRelatedWork W2079835038 @default.
- W2264708629 hasRelatedWork W2087715224 @default.
- W2264708629 hasRelatedWork W2096798951 @default.
- W2264708629 hasRelatedWork W2155499648 @default.
- W2264708629 hasRelatedWork W2264708629 @default.
- W2264708629 hasRelatedWork W2411323615 @default.
- W2264708629 hasRelatedWork W2412476936 @default.
- W2264708629 hasRelatedWork W2625653080 @default.
- W2264708629 hasVolume "277" @default.
- W2264708629 isParatext "false" @default.
- W2264708629 isRetracted "false" @default.
- W2264708629 magId "2264708629" @default.
- W2264708629 workType "article" @default.