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- W2264755416 abstract "Here we introduce a bio-interactive sensing platform that enables investigation of the migratory behavior of cells cultured on a flexible PDMS substrate. Unlike other approaches, a pure gradient of rigidity on the surface was achieved without the effect of surface morphology and surface chemistry maintained homogeneous. It is well known that the migration of cells is strongly affected by the rigidity of the surrounding environment in biological processes. To observe cell-substrate interaction thorough this biomechanical “sensing” in a more proper way, a PDMS layer was used to create a rigidity gradient between the stiff (2.5㎛) and soft (7.5㎛) regions of PDMS over a glass trench. The changes of surface rigidity were caused by the thickness variation of the PDMS layer on the glass structure. The stiffness change was 48.8% in normal direction (stiff: 2.9N/m, soft: 1.4N/m) and 25.5% in lateral direction (stiff 1N/m, soft: 0.8N/m), respectively. The result of migratory cell experiment clearly showed that the current cell preferred migrating toward the stiff region. These findings will provide important cues for cell differentiation and tissue engineering occurring through a bio-sensing mechanism." @default.
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- W2264755416 date "2009-11-01" @default.
- W2264755416 modified "2023-09-23" @default.
- W2264755416 title "Cell Response to Micro-patterned Polymeric Substrate with the Gradient of Rigidity" @default.
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