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• W2265004792 endingPage "295" @default.
• W2265004792 startingPage "279" @default.
• W2265004792 abstract "Aging induces structural and functional changes in the heart that are associated with increased risk of cardiovascular disease and impaired functional capacity in the elderly. Exercise is a diagnostic and therapeutic tool, with the potential to provide insights into clinical diagnosis and prognosis, as well as the molecular mechanisms by which aging influences cardiac physiology and function. In this review, we first provide an overview of how aging impacts the cardiac response to exercise, and the implications this has for functional capacity in older adults. We then review the underlying molecular mechanisms by which cardiac aging contributes to exercise intolerance, and conversely how exercise training can potentially modulate aging phenotypes in the heart. Finally, we highlight the potential use of these exercise models to complement models of disease in efforts to uncover new therapeutic targets to prevent or treat heart disease in the aging population." @default.
• W2265004792 created "2016-06-24" @default.
• W2265004792 creator A5050240892 @default.
• W2265004792 creator A5051837725 @default.
• W2265004792 creator A5077657690 @default.
• W2265004792 creator A5080760721 @default.
• W2265004792 date "2016-01-22" @default.
• W2265004792 modified "2023-10-17" @default.
• W2265004792 title "The Role of Exercise in Cardiac Aging" @default.
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