Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265014234> ?p ?o ?g. }
- W2265014234 endingPage "406" @default.
- W2265014234 startingPage "387" @default.
- W2265014234 abstract "Aging-related human diseases such as amyotrophic lateral sclerosis and Alzheimer's disease are both progressive and degenerative conditions for which no “natural” nonhuman animal models exist. Specific genes have been implicated in the etiology of both conditions, which has led to the development of transgenic rodent models that may mimic important aspects of the human disease. For Alzheimer's disease, mutations in the amyloid precursor protein and presenilin genes have been linked with familial forms of the disease, and apolipoprotein E gene allelic variations have been identified as risk factors. Transgenic studies have helped clarify the role of these genes in the development of Alzheimer's disease-related pathology, particularly with respect to Aβ amyloid plaque formation. Particular transgenic lines that express high levels of the mutated amyloid precursor protein gene and demonstrate aging-related Aβ deposition into plaques may mimic the earliest stages of Alzheimer's disease, representing an important tool for determining novel therapeutic strategies before substantial neurodegeneration has occurred. In amyotrophic lateral sclerosis, mutations in genes for Cu/Zn superoxide dismutase-1 and neurofilament proteins have been associated with a subset of cases, and transgenic models involving these genes have been shown to replicate important features of the human disease, particularly following aging. Thus, transgenic technology is advancing our understanding of the cause of pathology in human neurodegenerative diseases associated with aging and, perhaps more importantly, will provide an important resource for discovering and evaluating new methods to prevent these diseases." @default.
- W2265014234 created "2016-06-24" @default.
- W2265014234 creator A5075491523 @default.
- W2265014234 date "2001-01-01" @default.
- W2265014234 modified "2023-09-24" @default.
- W2265014234 title "Genetically Engineered Models of Human Age-Related Neurodegenerative Diseases" @default.
- W2265014234 cites W1482580692 @default.
- W2265014234 cites W1517477926 @default.
- W2265014234 cites W1528219518 @default.
- W2265014234 cites W1534001036 @default.
- W2265014234 cites W1565043637 @default.
- W2265014234 cites W1572812739 @default.
- W2265014234 cites W1574464726 @default.
- W2265014234 cites W1605023308 @default.
- W2265014234 cites W1617304195 @default.
- W2265014234 cites W1624264758 @default.
- W2265014234 cites W1637939020 @default.
- W2265014234 cites W1655404681 @default.
- W2265014234 cites W1675105744 @default.
- W2265014234 cites W1693283493 @default.
- W2265014234 cites W170366304 @default.
- W2265014234 cites W1836362700 @default.
- W2265014234 cites W1878737378 @default.
- W2265014234 cites W1886575365 @default.
- W2265014234 cites W1919811763 @default.
- W2265014234 cites W1920580857 @default.
- W2265014234 cites W193161715 @default.
- W2265014234 cites W1955472873 @default.
- W2265014234 cites W1958661641 @default.
- W2265014234 cites W1960315548 @default.
- W2265014234 cites W1963561572 @default.
- W2265014234 cites W1965496447 @default.
- W2265014234 cites W1965782812 @default.
- W2265014234 cites W1965806753 @default.
- W2265014234 cites W1966030100 @default.
- W2265014234 cites W1966954417 @default.
- W2265014234 cites W1968744160 @default.
- W2265014234 cites W1969530642 @default.
- W2265014234 cites W1971639674 @default.
- W2265014234 cites W1972481040 @default.
- W2265014234 cites W1972850922 @default.
- W2265014234 cites W1975906144 @default.
- W2265014234 cites W1977086524 @default.
- W2265014234 cites W1977683347 @default.
- W2265014234 cites W1977809930 @default.
- W2265014234 cites W1978000247 @default.
- W2265014234 cites W1978701238 @default.
- W2265014234 cites W1978932408 @default.
- W2265014234 cites W1979432217 @default.
- W2265014234 cites W1979543098 @default.
- W2265014234 cites W1980842500 @default.
- W2265014234 cites W1981554609 @default.
- W2265014234 cites W1983048518 @default.
- W2265014234 cites W1984309240 @default.
- W2265014234 cites W1986234504 @default.
- W2265014234 cites W1986695958 @default.
- W2265014234 cites W1992484817 @default.
- W2265014234 cites W1995219539 @default.
- W2265014234 cites W1995344309 @default.
- W2265014234 cites W1995515835 @default.
- W2265014234 cites W1998702457 @default.
- W2265014234 cites W2001210466 @default.
- W2265014234 cites W2001688761 @default.
- W2265014234 cites W2002156069 @default.
- W2265014234 cites W2004524375 @default.
- W2265014234 cites W2005681172 @default.
- W2265014234 cites W2005899728 @default.
- W2265014234 cites W2009945323 @default.
- W2265014234 cites W2011575330 @default.
- W2265014234 cites W2012076369 @default.
- W2265014234 cites W2012533473 @default.
- W2265014234 cites W2012851706 @default.
- W2265014234 cites W2013135033 @default.
- W2265014234 cites W2013471403 @default.
- W2265014234 cites W2013473672 @default.
- W2265014234 cites W2014253732 @default.
- W2265014234 cites W2015420496 @default.
- W2265014234 cites W2015859225 @default.
- W2265014234 cites W2016159899 @default.
- W2265014234 cites W2016870828 @default.
- W2265014234 cites W2016921733 @default.
- W2265014234 cites W2018465654 @default.
- W2265014234 cites W2018908557 @default.
- W2265014234 cites W2020274354 @default.
- W2265014234 cites W2020417668 @default.
- W2265014234 cites W2020675634 @default.
- W2265014234 cites W2021118737 @default.
- W2265014234 cites W2021333248 @default.
- W2265014234 cites W2021590064 @default.
- W2265014234 cites W2022367303 @default.
- W2265014234 cites W2022644599 @default.
- W2265014234 cites W2022907394 @default.
- W2265014234 cites W2023511811 @default.
- W2265014234 cites W2024098928 @default.
- W2265014234 cites W2024363942 @default.
- W2265014234 cites W2025516399 @default.
- W2265014234 cites W2028535633 @default.
- W2265014234 cites W2028542661 @default.