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- W2265142211 abstract "Nine Beagle dogs were exposed to aerosols of ${}^{90}{rm Y}$ in fused clay and examined serially using pulmonary function, clinical, and radiographic evaluations to better describe the pathogenesis of pulmonary damage resulting from the inhalation of beta-emitting radionuclides. The inhalation exposure resulted in initial lung burdens (ILB) of 390 to 920 μCi ${}^{90}{rm Y}/{rm kg}$ body weight and cumulative doses to the lung of 4900 to 12,000 rads. The evaluation of pulmonary function included measurements of ventilation, lung mechanics, gas exchange, and parameters obtained under the stresses of treadmill exercise and added external respiratory dead space. Functional alterations appeared in all exposed dogs at approximately 8 wk postinhalation exposure and the severity and rapidity of progression of dysfunction was related to dose. Early functional impairments included defects in the distribution of ventilation and in alveolar-capillary gas exchange. Later, t..." @default.
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- W2265142211 date "1973-10-01" @default.
- W2265142211 modified "2023-09-26" @default.
- W2265142211 title "The Effects of Inhaled 90 Y Fused Clay Aerosol on Pulmonary Function and Related Parameters of the Beagle Dog" @default.
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- W2265142211 doi "https://doi.org/10.2307/3573793" @default.
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