FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265223650> ?p ?o ?g. }

• W2265223650 endingPage "990" @default.
• W2265223650 startingPage "978" @default.
• W2265223650 abstract "Spray-dried dispersions (SDDs) are fascinating polymer–drug mixtures that exploit the amorphous state of a drug to dramatically elevate its apparent aqueous solubility above equilibrium. For practical usage in oral delivery, understanding how polymers mechanistically provide physical stability during storage and prevent supersaturated drugs from succumbing to precipitation during dissolution remains a formidable challenge. To this end, we developed a versatile polymeric platform with functional groups analogous to hydroxypropyl methyl cellulose acetate succinate (HPMCAS, a heterogeneous leading excipient candidate for SDDs) and studied its interactions with Biopharmaceutical Classification System Class II drug models probucol, danazol, and phenytoin at various dosages. By conducting reversible addition–fragmentation chain transfer polymerizations with monomeric components chemically analogous to HPMCAS, we synthetically dismantled the highly polydisperse architecture of HPMCAS into well-defined polymer systems (i.e., targetable Mn, Đ < 1.3, tunable Tg). In the powdered SDD form, by wide-angle X-ray diffraction all HPMCAS analogs yielded amorphous danazol and phenytoin up to 50 wt % loading, whereas for probucol, hydrophobic methoxy functionality and high polymeric Tg were key to inhibit immediate partitioning into crystalline domains. Nonsink in vitro dissolution tests revealed distinct release profiles. The polymer containing only acetyl and succinoyl substituents spray-dried with probucol increased the area under the dissolution curve by a factor of 180, 112, and 26 over pure drug at 10, 25, and 50 wt % loading, respectively. For crystallization-prone danazol and phenytoin, we observed that the water-soluble polymer with hydroxyl groups inhibited crystal growth and enabled high burst release and supersaturation maintenance. Our findings provide fundamental insight into how excipient microstructures can complex with drugs for excipient formulation applications." @default.
• W2265223650 created "2016-06-24" @default.
• W2265223650 creator A5001586739 @default.
• W2265223650 creator A5055008593 @default.
• W2265223650 creator A5069824583 @default.
• W2265223650 creator A5086211096 @default.
• W2265223650 creator A5087411432 @default.
• W2265223650 date "2015-09-10" @default.
• W2265223650 modified "2023-10-14" @default.
• W2265223650 title "Deconstructing HPMCAS: Excipient Design to Tailor Polymer–Drug Interactions for Oral Drug Delivery" @default.
• W2265223650 cites W1590254871 @default.
• W2265223650 cites W1965469157 @default.
• W2265223650 cites W1968804888 @default.
• W2265223650 cites W1975230163 @default.
• W2265223650 cites W1981547314 @default.
• W2265223650 cites W1984548348 @default.
• W2265223650 cites W1998612140 @default.
• W2265223650 cites W2000004607 @default.
• W2265223650 cites W2027375772 @default.
• W2265223650 cites W2029112828 @default.
• W2265223650 cites W2032012679 @default.
• W2265223650 cites W2033387736 @default.
• W2265223650 cites W2041517295 @default.
• W2265223650 cites W2053678343 @default.
• W2265223650 cites W2055294298 @default.
• W2265223650 cites W2062629587 @default.
• W2265223650 cites W2069235788 @default.
• W2265223650 cites W2071551353 @default.
• W2265223650 cites W2071871708 @default.
• W2265223650 cites W2092146868 @default.
• W2265223650 cites W2099540110 @default.
• W2265223650 cites W2101945100 @default.
• W2265223650 cites W2110604072 @default.
• W2265223650 cites W2112135623 @default.
• W2265223650 cites W2121780278 @default.
• W2265223650 cites W2133061394 @default.
• W2265223650 cites W2139338896 @default.
• W2265223650 cites W2161915811 @default.
• W2265223650 cites W2312868038 @default.
• W2265223650 cites W2314754780 @default.
• W2265223650 cites W2315100182 @default.
• W2265223650 cites W2321365258 @default.
• W2265223650 cites W2322190906 @default.
• W2265223650 cites W2322570926 @default.
• W2265223650 cites W2324818055 @default.
• W2265223650 cites W2326468474 @default.
• W2265223650 cites W2413368107 @default.
• W2265223650 cites W2596374928 @default.
• W2265223650 cites W2598042565 @default.
• W2265223650 doi "https://doi.org/10.1021/acsbiomaterials.5b00234" @default.
• W2265223650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33429529" @default.
• W2265223650 hasPublicationYear "2015" @default.
• W2265223650 type Work @default.
• W2265223650 sameAs 2265223650 @default.
• W2265223650 citedByCount "45" @default.
• W2265223650 countsByYear W22652236502016 @default.
• W2265223650 countsByYear W22652236502017 @default.
• W2265223650 countsByYear W22652236502018 @default.
• W2265223650 countsByYear W22652236502019 @default.
• W2265223650 countsByYear W22652236502020 @default.
• W2265223650 countsByYear W22652236502021 @default.
• W2265223650 countsByYear W22652236502022 @default.
• W2265223650 countsByYear W22652236502023 @default.
• W2265223650 crossrefType "journal-article" @default.
• W2265223650 hasAuthorship W2265223650A5001586739 @default.
• W2265223650 hasAuthorship W2265223650A5055008593 @default.
• W2265223650 hasAuthorship W2265223650A5069824583 @default.
• W2265223650 hasAuthorship W2265223650A5086211096 @default.
• W2265223650 hasAuthorship W2265223650A5087411432 @default.
• W2265223650 hasBestOaLocation W22652236501 @default.
• W2265223650 hasConcept C127413603 @default.
• W2265223650 hasConcept C155574463 @default.
• W2265223650 hasConcept C171250308 @default.
• W2265223650 hasConcept C178790620 @default.
• W2265223650 hasConcept C185592680 @default.
• W2265223650 hasConcept C192562407 @default.
• W2265223650 hasConcept C200447597 @default.
• W2265223650 hasConcept C2776167589 @default.
• W2265223650 hasConcept C2777239854 @default.
• W2265223650 hasConcept C2778004101 @default.
• W2265223650 hasConcept C2779820397 @default.
• W2265223650 hasConcept C42360764 @default.
• W2265223650 hasConcept C43617362 @default.
• W2265223650 hasConcept C46275449 @default.
• W2265223650 hasConcept C521977710 @default.
• W2265223650 hasConcept C56052488 @default.
• W2265223650 hasConcept C8010536 @default.
• W2265223650 hasConcept C88380143 @default.
• W2265223650 hasConceptScore W2265223650C127413603 @default.
• W2265223650 hasConceptScore W2265223650C155574463 @default.
• W2265223650 hasConceptScore W2265223650C171250308 @default.
• W2265223650 hasConceptScore W2265223650C178790620 @default.
• W2265223650 hasConceptScore W2265223650C185592680 @default.
• W2265223650 hasConceptScore W2265223650C192562407 @default.
• W2265223650 hasConceptScore W2265223650C200447597 @default.
• W2265223650 hasConceptScore W2265223650C2776167589 @default.
• W2265223650 hasConceptScore W2265223650C2777239854 @default.
• W2265223650 hasConceptScore W2265223650C2778004101 @default.

• next