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- W2265529440 abstract "Despite recent advances in hemodialysis (HD) technology. The overall outcome of patients on conventional HD remains miserably unsatisfactory with a 5-year patient survival rate of 30% in the United States. In search of better HD modalities, a number of investigators in Europe and North America have reported greatly improved outcome with prolonged and/or frequent RD. These include 8h, 3-times-weekly HD from Tassin, France, every-other-day or 4-times-weekly HD from Lecce, Italy, Short daily HD (SDHD) from Perugia, Italy, and nocturnal HD (NHD) from Toronto, Canada, with increasing number of other SDHD and NHD programs reported in recent years. The prolonged and/or frequent HD allows better clearance of solutes, smooth ultrafiltration with good control of hypertension, avoidance of solute rebound and disequilibrium symptoms, liberalization of diet with improved nutrition, and better neuro-cognitive function. In addition, NHD is associated with correction of hyperphosphatemia without the use of phosphate binders, improved removal of middle molecules such as β2 microglobulin, and effective control of sleep apnea. Above all, in all of these HD modalities, patient survival is remarkably improved with reduction in hospitalization, and the better quality of life leads to good rehabilitation. Although these reports are based on anecdotal experiences, many with selected groups of patients, the impressive improvement in patient outcome makes it worthwhile to further pursue large scale controlled studies for confirmation as well as for the future guide to improve HD modalities." @default.
- W2265529440 created "2016-06-24" @default.
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- W2265529440 date "2002-01-01" @default.
- W2265529440 modified "2023-09-24" @default.
- W2265529440 title "Hemodialysis of the Future: Prolonged and/or Frequent Dialysis" @default.
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