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- W2265570435 abstract "Dengue has emerged to be global health problem worldwide. Hence there is an immediate need to adopt new strategies in the development of effective anti-dengue drugs. Extracts from the leaves of Azadirachta indica has been traditionally used in folk medicine for viral infections. In the present study we report the anti-viral potency of nimbin, the active compound from the neem leaf extract against the envelope protein of dengue virus. Progression of viral entry into the host cell is facilitated by the envelope protein of dengue virus, suggesting; it as an effective anti-viral target. Nimbin is found to be effective against the envelope protein of all four types of dengue virus (dengue 1-4), which is evident from our in silico analysis. Our findings suggest the clinical importance of nimbin, which can serve as effective lead compound for further analysis." @default.
- W2265570435 created "2016-06-24" @default.
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- W2265570435 date "2015-11-20" @default.
- W2265570435 modified "2023-10-02" @default.
- W2265570435 title "Computational analysis reveal inhibitory action of nimbin against dengue viral envelope protein" @default.
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- W2265570435 doi "https://doi.org/10.1007/s13337-015-0280-x" @default.
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