FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265610056> ?p ?o ?g. }

• W2265610056 abstract "Abstract Dasatinib(SPRYCEL®) is a kinase inhibitor active against BCR-ABL and SRC family kinases. A phase I trial of dasatinib has shown CHR and MCyR at total daily doses of 100 mg and 140 mg daily in both BID and once daily (QD) schedule in CML-CP patients (pts). Phase II studies of dasatinib have demonstrated the efficacy and safety of a 70 mg twice daily (BID) dose in CML-CP pts with resistance or intolerance to imatinib. We analyzed safety and adverse events (AE) data in 27 pts with CML (CP), imatinib resistant (85%) or intolerant (15%), who have been treated with dasatinib from May 2006 to July 2007 in a compassionate use in Italy. A possible relationship of AE observed during dasatinib with imatinib toxicity and previous types of treatment was analyzed. Median age was 52 years at diagnosis and 58,6 years at start of dasatinib. Sokal was low in 22%, intermediate in 33%, high in 15%, not available in 30%. The median time from CML diagnosis to enrollment in the compassionate use was 78 months. Imatinib dosage, administered during the previous 3 months, was 400 mg/d in 40% of pts, 400–600 mg/d in 50% and >600 mg/d in 10% . Prior treatment for CML included interferon alpha in 48%, chemotherapy in 18%, nilotinib in 18% of the cases and stem cell transplant (SCT) in 1 case. Additional chromosome anomalies and mutations were observed in 18% and 55% of cases, respectively. Dasatinib was administered 70 mg BID, and dose escalation to 100 mg BID and reduction to 50 mg BID or 40 mg BID were allowed for inadequate response or AE. Hematological toxicity during imatinib treatment was reported in 55% of the cases as first episode, and 30% as second episode; extrahematological toxicity was also 55%. Following dasatinib treatment, 70% of the patients had some degree of hematologic toxicity with 21 events. 95% of these AE occurred in the first 2 months of treatment, with 80% in the first month. A second episode of hematolological toxicity was observed in 26% of the cases between months 2 and 15 (median mo. 5). Overall, neutropenia was observed in 11 patients (grade 4 in 5), thromobocytopenia in 11(grade 3 or less) and anemia in 4(grade 4 in one).13 patients have complained of non. hematological toxicity, with 15 AE with grade >2 occurring in the first 40 days. Further AEs were rare and non clinically relevant. The only grade 4 AE was pulmonary oedema; grade 3 AE were fever, arthralgia, liver toxicity, fluid retention; one grade 2 pleural effusion was reported. 48% of cases reduced dosage, whereas only one increased due to lack of response: this patient is now undergoing an allogeneic SCT One patient died, after stop for fluid retention, because of sepsis. All the other patients are still on therapy with a follow-up ranging from 2 to 15 months (median 6 mo). Hematological toxicity during dasatinib was not related to the number of previous treatments and to the time on imatinib. In conclusion, therapy with dasatinib is generally well tolerated, and side effects are reduced by a correct use and clinical surveillance of the patients; in addition, we found that both hematological and extrahematological toxicities decline with time and are not related to the previous treatment." @default.
• W2265610056 created "2016-06-24" @default.
• W2265610056 creator A5001285087 @default.
• W2265610056 creator A5002679835 @default.
• W2265610056 creator A5006110055 @default.
• W2265610056 creator A5011435773 @default.
• W2265610056 creator A5026176228 @default.
• W2265610056 creator A5039757859 @default.
• W2265610056 creator A5043495691 @default.
• W2265610056 creator A5054124337 @default.
• W2265610056 creator A5057593886 @default.
• W2265610056 creator A5078324992 @default.
• W2265610056 creator A5080563685 @default.
• W2265610056 creator A5089760320 @default.
• W2265610056 creator A5090108654 @default.
• W2265610056 date "2007-11-16" @default.
• W2265610056 modified "2023-10-18" @default.
• W2265610056 title "Improvement of Tolerability and Adverse Events Occurrence during Treatment with Dasatinib Used on a Compassionate Basis in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP)." @default.
• W2265610056 doi "https://doi.org/10.1182/blood.v110.11.4564.4564" @default.
• W2265610056 hasPublicationYear "2007" @default.
• W2265610056 type Work @default.
• W2265610056 sameAs 2265610056 @default.
• W2265610056 citedByCount "0" @default.
• W2265610056 crossrefType "journal-article" @default.
• W2265610056 hasAuthorship W2265610056A5001285087 @default.
• W2265610056 hasAuthorship W2265610056A5002679835 @default.
• W2265610056 hasAuthorship W2265610056A5006110055 @default.
• W2265610056 hasAuthorship W2265610056A5011435773 @default.
• W2265610056 hasAuthorship W2265610056A5026176228 @default.
• W2265610056 hasAuthorship W2265610056A5039757859 @default.
• W2265610056 hasAuthorship W2265610056A5043495691 @default.
• W2265610056 hasAuthorship W2265610056A5054124337 @default.
• W2265610056 hasAuthorship W2265610056A5057593886 @default.
• W2265610056 hasAuthorship W2265610056A5078324992 @default.
• W2265610056 hasAuthorship W2265610056A5080563685 @default.
• W2265610056 hasAuthorship W2265610056A5089760320 @default.
• W2265610056 hasAuthorship W2265610056A5090108654 @default.
• W2265610056 hasConcept C126322002 @default.
• W2265610056 hasConcept C143998085 @default.
• W2265610056 hasConcept C197934379 @default.
• W2265610056 hasConcept C2777413986 @default.
• W2265610056 hasConcept C2777583451 @default.
• W2265610056 hasConcept C2778375690 @default.
• W2265610056 hasConcept C2778729363 @default.
• W2265610056 hasConcept C2779536868 @default.
• W2265610056 hasConcept C3019892230 @default.
• W2265610056 hasConcept C71924100 @default.
• W2265610056 hasConcept C90924648 @default.
• W2265610056 hasConceptScore W2265610056C126322002 @default.
• W2265610056 hasConceptScore W2265610056C143998085 @default.
• W2265610056 hasConceptScore W2265610056C197934379 @default.
• W2265610056 hasConceptScore W2265610056C2777413986 @default.
• W2265610056 hasConceptScore W2265610056C2777583451 @default.
• W2265610056 hasConceptScore W2265610056C2778375690 @default.
• W2265610056 hasConceptScore W2265610056C2778729363 @default.
• W2265610056 hasConceptScore W2265610056C2779536868 @default.
• W2265610056 hasConceptScore W2265610056C3019892230 @default.
• W2265610056 hasConceptScore W2265610056C71924100 @default.
• W2265610056 hasConceptScore W2265610056C90924648 @default.
• W2265610056 hasLocation W22656100561 @default.
• W2265610056 hasOpenAccess W2265610056 @default.
• W2265610056 hasPrimaryLocation W22656100561 @default.
• W2265610056 hasRelatedWork W1161292135 @default.
• W2265610056 hasRelatedWork W1965816291 @default.
• W2265610056 hasRelatedWork W1966530290 @default.
• W2265610056 hasRelatedWork W1991773845 @default.
• W2265610056 hasRelatedWork W2116887545 @default.
• W2265610056 hasRelatedWork W2556113557 @default.
• W2265610056 hasRelatedWork W2793625425 @default.
• W2265610056 hasRelatedWork W3105368855 @default.
• W2265610056 hasRelatedWork W32471882 @default.
• W2265610056 hasRelatedWork W4205315915 @default.
• W2265610056 isParatext "false" @default.
• W2265610056 isRetracted "false" @default.
• W2265610056 magId "2265610056" @default.
• W2265610056 workType "article" @default.