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• W2265624492 abstract "Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a reported risk factor for dementia. However, the relationship between Alzheimer's disease (AD) and Lp-PLA2 is still debatable and, to the best of our knowledge, no study has evaluated the associations between levels of Lp-PLA2, proinflammatory cytokines, and neopterin in AD. In total, 59 patients with AD and 38 non-demented individuals were included in the case–control study. Fasting serum concentrations of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin, and Lp-PLA2 were determined using ELISA. The associations between AD and each of the variables were analyzed by logistic regression. The median Lp-PLA2 levels in AD and controls were similar (P = 0.29, not significant). Median serum neopterin and IL-6 levels were significantly higher in patients with AD than in controls (P = 0.0001 and P = 0.03, respectively). In regression analyses, median neopterin levels, a lower level of education, and female gender were significantly associated with AD when compared with controls (OR, 31.44, 95% CI 3.59–275.28, P = 0.002; OR, 4.35, 95% CI 1.13–16.61, P = 0.032; OR, 7.25, 95% CI 1.88–28.00, P = 0.004, respectively). In contrast to previous evidence suggesting its role in dementia and AD, Lp-PLA2 enzyme levels were higher in the controls, and no relationship between Lp-PLA2 and either proinflammatory cytokines or neopterin was identified in AD. Elevated neopterin levels may be considered inflammatory markers of AD." @default.
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• W2265624492 date "2016-05-01" @default.
• W2265624492 modified "2023-10-16" @default.
• W2265624492 title "No relationship between lipoprotein-associated phospholipase A2, proinflammatory cytokines, and neopterin in Alzheimer's disease" @default.
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• W2265624492 doi "https://doi.org/10.1016/j.exger.2016.01.014" @default.
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