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• W2265629191 abstract "xix RESUMO xxi OUTLINE OF THE THESIS xxiii TABLE OF CONTENTS xxv LIST OF FIGURES xxvii LIST OF TABLES xxix LIST OF ABBREVIATIONS xxxi CHAPTER I: INTRODUCTION 1 1.1 Pain classification and general concepts 3 1.2 Pain neurophysiology 7 1.2.1 Peripheral pain mechanisms 7 1.2.2 Central perspective – dorsal horn mechanisms 10 1.2.3 Interconnections in pain modulation 12 1.2.3.1 Ascending pathways 13 1.2.3.2 Descending pathways 14 1.3 Cancer-related pain management 15 1.3.1 Pain assessment 19 1.3.2 Pharmacological approaches 21 1.3.2.1 Non-opioid analgesics 21 1.3.2.2 Opioid analgesics 24 1.3.2.2.1 Mild to moderate pain 26 1.3.2.2.2 Moderate to severe pain 27 1.3.2.2.3 Breakthrough pain 29 1.3.2.3 Adjuvant drugs for analgesia 30 1.3.2.2.1 Antidepressant drugs 31 1.3.2.2.2 Anticonvulsant drugs 31 1.3.2.2.3 Oral and local anesthetic agents 32 1.3.2.2.4 Bone pain and bisphosphonates 32 1.3.2.2.5 Corticosteroids 33 1.3.2.2.6 Cannabinoids 33 1.3.2.2.7 Ketamine and dextromethorphan 34 1.3.2.4 Other analgesic / adjuvant agents and future perspectives 34 1.4 Genetic polymorphisms, pain perception and morphine requirements 35 1.4.1 Pain transmission and perception 36 1.4.1.1 Catecholaminergic and serotoninergic systems 36 1.4.1.1.1 Metabolism: catechol-O-methyl transferase and monoamine oxidases 36" @default.
• W2265629191 created "2016-06-24" @default.
• W2265629191 creator A5026446188 @default.
• W2265629191 date "2014-03-03" @default.
• W2265629191 modified "2023-09-27" @default.
• W2265629191 title "Study of Genetic Factors Involved in Pain Perception and Morphine Analgesia in Cancer-Related Pain" @default.
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• W2265629191 hasPublicationYear "2014" @default.
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