FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265652906> ?p ?o ?g. }

• W2265652906 endingPage "290" @default.
• W2265652906 startingPage "284" @default.
• W2265652906 abstract "Background The roles of GABA, serotonin, dopamine, and alcohol metabolism pathways in alcohol dependence (AD) are evident from animal models and human studies. Aims of this study were to investigate associations between genes in the 4 pathways and AD. Methods Male subjects from 2 independent samples of Taiwanese Han descent, a family sample of 179 trios and a case–control sample of 262 AD cases and 273 normal controls, were included in this study. The Schedules for Clinical Assessment in Neuropsychiatry was used for phenotype assessment of AD. We genotyped 282 single nucleotide polymorphisms (SNPs) located in 61 candidate genes involving alcohol metabolism, serotonin, and GABA systems among the family sample and replicated the top hits in the case–control sample. Results Fifteen SNPs located in 10 genes showed signals of associations (FBAT test p < 0.05) with AD in the family sample. Three SNPs, rs1229984 in ADH1B , rs671 in ALDH2, and rs2000292 in HTR1B , were significantly replicated in the case–control sample ( p = 5.87 × 10 −14 , 5.12 × 10 −14 , and 0.0051, respectively). In the combined meta‐analysis, these 3 SNPs and 1 additional SNP, rs698 in ADH1C , showed significant association after correcting for multiple comparisons, and rs1229984 and rs671 showed the strongest association ( p < 10 −16 ). Logistic regression conditioning on rs1229984 and rs671 in the case–control sample showed that rs2000292 in HTR1B remained nominally significant. Conclusions Genes in alcohol metabolism pathway, especially ADH1 B and ALDH2 , conferred the major genetic risk for AD in Taiwanese Han population. Some genes in GABA and serotonin pathways showed nominal association with AD." @default.
• W2265652906 created "2016-06-24" @default.
• W2265652906 creator A5070866756 @default.
• W2265652906 creator A5074444847 @default.
• W2265652906 creator A5078745995 @default.
• W2265652906 creator A5080257216 @default.
• W2265652906 creator A5088384934 @default.
• W2265652906 date "2016-02-01" @default.
• W2265652906 modified "2023-10-15" @default.
• W2265652906 title "Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men" @default.
• W2265652906 cites W1496729474 @default.
• W2265652906 cites W1501337774 @default.
• W2265652906 cites W1547613518 @default.
• W2265652906 cites W1969928171 @default.
• W2265652906 cites W1977467968 @default.
• W2265652906 cites W1979803024 @default.
• W2265652906 cites W1986855121 @default.
• W2265652906 cites W1987837762 @default.
• W2265652906 cites W1990492104 @default.
• W2265652906 cites W1991475702 @default.
• W2265652906 cites W1991645988 @default.
• W2265652906 cites W2005651592 @default.
• W2265652906 cites W2008710752 @default.
• W2265652906 cites W2008881692 @default.
• W2265652906 cites W2016392942 @default.
• W2265652906 cites W2016897420 @default.
• W2265652906 cites W2016926635 @default.
• W2265652906 cites W2026551896 @default.
• W2265652906 cites W2031435056 @default.
• W2265652906 cites W2031629203 @default.
• W2265652906 cites W2039303909 @default.
• W2265652906 cites W2045343752 @default.
• W2265652906 cites W2051758054 @default.
• W2265652906 cites W2053528384 @default.
• W2265652906 cites W2059723753 @default.
• W2265652906 cites W2071944144 @default.
• W2265652906 cites W2079943120 @default.
• W2265652906 cites W2087346597 @default.
• W2265652906 cites W2098701344 @default.
• W2265652906 cites W2105952206 @default.
• W2265652906 cites W2107747730 @default.
• W2265652906 cites W2111666128 @default.
• W2265652906 cites W2111925968 @default.
• W2265652906 cites W2113445887 @default.
• W2265652906 cites W2119710998 @default.
• W2265652906 cites W2121955249 @default.
• W2265652906 cites W2127071058 @default.
• W2265652906 cites W2138374031 @default.
• W2265652906 cites W2141636993 @default.
• W2265652906 cites W2146022716 @default.
• W2265652906 cites W2149105021 @default.
• W2265652906 cites W2155661977 @default.
• W2265652906 cites W2160224446 @default.
• W2265652906 cites W2171703074 @default.
• W2265652906 cites W2315535280 @default.
• W2265652906 cites W2721775012 @default.
• W2265652906 cites W3022979753 @default.
• W2265652906 cites W4247258387 @default.
• W2265652906 cites W4252076974 @default.
• W2265652906 doi "https://doi.org/10.1111/acer.12963" @default.
• W2265652906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26842247" @default.
• W2265652906 hasPublicationYear "2016" @default.
• W2265652906 type Work @default.
• W2265652906 sameAs 2265652906 @default.
• W2265652906 citedByCount "11" @default.
• W2265652906 countsByYear W22656529062017 @default.
• W2265652906 countsByYear W22656529062018 @default.
• W2265652906 countsByYear W22656529062019 @default.
• W2265652906 countsByYear W22656529062020 @default.
• W2265652906 countsByYear W22656529062021 @default.
• W2265652906 crossrefType "journal-article" @default.
• W2265652906 hasAuthorship W2265652906A5070866756 @default.
• W2265652906 hasAuthorship W2265652906A5074444847 @default.
• W2265652906 hasAuthorship W2265652906A5078745995 @default.
• W2265652906 hasAuthorship W2265652906A5080257216 @default.
• W2265652906 hasAuthorship W2265652906A5088384934 @default.
• W2265652906 hasConcept C104317684 @default.
• W2265652906 hasConcept C135763542 @default.
• W2265652906 hasConcept C139275648 @default.
• W2265652906 hasConcept C151325109 @default.
• W2265652906 hasConcept C153209595 @default.
• W2265652906 hasConcept C181199279 @default.
• W2265652906 hasConcept C186413461 @default.
• W2265652906 hasConcept C2776317432 @default.
• W2265652906 hasConcept C2779436514 @default.
• W2265652906 hasConcept C2781066024 @default.
• W2265652906 hasConcept C54355233 @default.
• W2265652906 hasConcept C55493867 @default.
• W2265652906 hasConcept C71924100 @default.
• W2265652906 hasConcept C86803240 @default.
• W2265652906 hasConcept C96722902 @default.
• W2265652906 hasConceptScore W2265652906C104317684 @default.
• W2265652906 hasConceptScore W2265652906C135763542 @default.
• W2265652906 hasConceptScore W2265652906C139275648 @default.
• W2265652906 hasConceptScore W2265652906C151325109 @default.
• W2265652906 hasConceptScore W2265652906C153209595 @default.
• W2265652906 hasConceptScore W2265652906C181199279 @default.
• W2265652906 hasConceptScore W2265652906C186413461 @default.

• next