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- W226566826 abstract "Objective To explore the Crk expression in breast cancer and its clinical significance. Methods The expression of Crk was detected in 125 breast cancer tissues and 20 benign tumor tissues by immunohistochemistry and the relationship with clinicopathological parameters and prognosis was analyzed. Results The positive rate of Crk expression in breast cancer was 39.2%,which was significantly higher than that in benign tumor tissues of breast(χ2=6.447,P=0.011).Crk expression related to histologic grade (χ2=4.965,P=0.026),and correlated positively with TNM stage (r=0.258,P=0.004),lymph node status(r=0.261,P=0.004) and HER-2 status(r=0.287,P=0.021).In addition,Kaplan-Meier curves of disease-specific survival analysis showed a significant difference between Crk positive group and negative group (P=0.018). Conclusions Crk protein expression is up-regulated in primary breast cancer,indicating a more aggressive phenotype and poor prognosis.Crk detection may provide valuable information for risk assessment and identify a subset of patients requiring more aggressive adjuvant therapy." @default.
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- W226566826 date "2009-01-01" @default.
- W226566826 modified "2023-09-27" @default.
- W226566826 title "Expression of Crk protein in breast cancer and its clinical significance." @default.
- W226566826 hasPublicationYear "2009" @default.
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