FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265794057> ?p ?o ?g. }

• W2265794057 abstract "Hepatitis C virus genotype 2 (HCV-2) slow responders poorly respond to 24 weeks of peginterferon (Peg-IFN) plus ribavirin (RBV). We evaluated the efficacy of extended 48-week regimen and the role of interleukin-28B (IL-28B) genotype in this clinical setting. Treatment-naïve HCV-2 patients not achieving rapid virologic response (RVR) by Peg-IFN alfa-2a 180 μg/week plus weight-based RBV (1,000-1,200 mg/day, cutoff body weight of 75 kg) were randomly assigned to receive a total duration of 48 (n = 94) or 24 (n = 93) weeks of therapy. The primary endpoint was sustained virologic response (SVR). Baseline patient characteristics to predict SVR were analyzed. Patients receiving 48 weeks of treatment had a greater SVR rate than those receiving 24 weeks of treatment (70.2% versus 46.2%, P = 0.001). Compared to patients treated for 24 weeks, the SVR rate in those treated for 48 weeks increased by 10.9% [95% CI: -5.9% to 27.7%] and 65.6% [95% CI: 44.5% to 86.7%] if they had IL-28B rs8099917 TT genotype, and GT/GG genotype, respectively (interaction P = 0.002). In conclusion, 48-week treatment with Peg-IFN plus weight-based RBV provides a greater SVR rate than 24-week treatment in treatment-naïve HCV-2 patients with unfavorable IL-28B genotypes who fail to achieve RVR." @default.
• W2265794057 created "2016-06-24" @default.
• W2265794057 creator A5005714550 @default.
• W2265794057 creator A5009330208 @default.
• W2265794057 creator A5014821725 @default.
• W2265794057 creator A5032428542 @default.
• W2265794057 creator A5037214480 @default.
• W2265794057 creator A5039672232 @default.
• W2265794057 creator A5042614321 @default.
• W2265794057 creator A5043777518 @default.
• W2265794057 creator A5046862705 @default.
• W2265794057 creator A5051036746 @default.
• W2265794057 creator A5058253583 @default.
• W2265794057 creator A5061524286 @default.
• W2265794057 creator A5071989098 @default.
• W2265794057 creator A5072593323 @default.
• W2265794057 creator A5084553751 @default.
• W2265794057 creator A5085334248 @default.
• W2265794057 date "2015-07-01" @default.
• W2265794057 modified "2023-10-18" @default.
• W2265794057 title "Peginterferon plus weight-based ribavirin for treatment-naïve hepatitis C virus genotype 2 patients not achieving rapid virologic response: a randomized trial" @default.
• W2265794057 cites W1962777816 @default.
• W2265794057 cites W1970053808 @default.
• W2265794057 cites W1980771473 @default.
• W2265794057 cites W1981036435 @default.
• W2265794057 cites W1997865776 @default.
• W2265794057 cites W1998859748 @default.
• W2265794057 cites W2027545702 @default.
• W2265794057 cites W2031293151 @default.
• W2265794057 cites W2058582559 @default.
• W2265794057 cites W2063252675 @default.
• W2265794057 cites W2068111057 @default.
• W2265794057 cites W2073113951 @default.
• W2265794057 cites W2075282196 @default.
• W2265794057 cites W2078251659 @default.
• W2265794057 cites W2080672894 @default.
• W2265794057 cites W2092858485 @default.
• W2265794057 cites W2093919456 @default.
• W2265794057 cites W2093977114 @default.
• W2265794057 cites W2095217328 @default.
• W2265794057 cites W2100496319 @default.
• W2265794057 cites W2112876622 @default.
• W2265794057 cites W2120733999 @default.
• W2265794057 cites W2127685726 @default.
• W2265794057 cites W2131011125 @default.
• W2265794057 cites W2131988977 @default.
• W2265794057 cites W2133036275 @default.
• W2265794057 cites W2135776555 @default.
• W2265794057 cites W2140767287 @default.
• W2265794057 cites W2146392601 @default.
• W2265794057 cites W2147954883 @default.
• W2265794057 cites W2150064542 @default.
• W2265794057 cites W2150652264 @default.
• W2265794057 cites W2325791202 @default.
• W2265794057 cites W4210961054 @default.
• W2265794057 cites W4232907328 @default.
• W2265794057 doi "https://doi.org/10.1038/srep11710" @default.
• W2265794057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4486927" @default.
• W2265794057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26130141" @default.
• W2265794057 hasPublicationYear "2015" @default.
• W2265794057 type Work @default.
• W2265794057 sameAs 2265794057 @default.
• W2265794057 citedByCount "7" @default.
• W2265794057 countsByYear W22657940572015 @default.
• W2265794057 countsByYear W22657940572016 @default.
• W2265794057 countsByYear W22657940572017 @default.
• W2265794057 countsByYear W22657940572019 @default.
• W2265794057 crossrefType "journal-article" @default.
• W2265794057 hasAuthorship W2265794057A5005714550 @default.
• W2265794057 hasAuthorship W2265794057A5009330208 @default.
• W2265794057 hasAuthorship W2265794057A5014821725 @default.
• W2265794057 hasAuthorship W2265794057A5032428542 @default.
• W2265794057 hasAuthorship W2265794057A5037214480 @default.
• W2265794057 hasAuthorship W2265794057A5039672232 @default.
• W2265794057 hasAuthorship W2265794057A5042614321 @default.
• W2265794057 hasAuthorship W2265794057A5043777518 @default.
• W2265794057 hasAuthorship W2265794057A5046862705 @default.
• W2265794057 hasAuthorship W2265794057A5051036746 @default.
• W2265794057 hasAuthorship W2265794057A5058253583 @default.
• W2265794057 hasAuthorship W2265794057A5061524286 @default.
• W2265794057 hasAuthorship W2265794057A5071989098 @default.
• W2265794057 hasAuthorship W2265794057A5072593323 @default.
• W2265794057 hasAuthorship W2265794057A5084553751 @default.
• W2265794057 hasAuthorship W2265794057A5085334248 @default.
• W2265794057 hasBestOaLocation W22657940571 @default.
• W2265794057 hasConcept C104317684 @default.
• W2265794057 hasConcept C126322002 @default.
• W2265794057 hasConcept C135763542 @default.
• W2265794057 hasConcept C142462285 @default.
• W2265794057 hasConcept C168563851 @default.
• W2265794057 hasConcept C203014093 @default.
• W2265794057 hasConcept C203092338 @default.
• W2265794057 hasConcept C2522874641 @default.
• W2265794057 hasConcept C2776408679 @default.
• W2265794057 hasConcept C2776455275 @default.
• W2265794057 hasConcept C2780040827 @default.
• W2265794057 hasConcept C2781399841 @default.
• W2265794057 hasConcept C2781413609 @default.
• W2265794057 hasConcept C55493867 @default.
• W2265794057 hasConcept C71924100 @default.

• next