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- W2265796149 abstract "Dysentery and typhoid vaccines were prepared from organisms killed by -exposure ---radioactive (RV) and polysaccharide-protein antigenic complexes --radioactive antigens (RA). In experiments on animals it was shown that the toxicity of RV and RA did not differ from that of the usual formalized vaccine (FV) and the antigenic complexes. The toxicity of typhoid RV, determined by a subcutaneous reaction in rabbits, was somewhat less than the toxicity of FV. RV was less reactive than the heated and FV. The anaphylactic properties of both types of vaccine were the same. The antigenic properties of RV and the usual vaccines (experiments on rabbits with determination of agglutination titer) were analogous. The immunological properties were studied by immunization of mice with both forms of vaccine by an identical schedule with subsequent infection. The immunogenic properties of dysentery RV did not differ from those of FV. Radiation of FV evoked a negligible decrease of its immunogenic properties. The immunological properties of the typhoid RV after a 4-month storage were higher than those of the heated typhoid vaccine and FV. Similar data were obtained in a study of the immunological properties of RA. The ability of RV and RA to call forth the formationmore » of protective antibody did not diverge from that of the usual vaccines and antigens. Using RGA (radioactive gamma antigen) it was shown that the Vi-antigen was preserved in irradiated cultures. The authors believe that - rays can be utilized for the preparation of intestinal vaccines and antigens as well as for the sterilization of correspondingly prepared bacterial preparations. (auth)« less" @default.
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- W2265796149 date "1958-01-01" @default.
- W2265796149 modified "2023-09-24" @default.
- W2265796149 title "INFLUENCE OF MASSIVE DOSES OF $gamma$-RAYS ON IMMUNOLOGICAL PROPERTIES OF BACTERIA OF INTESTINAL GROUP" @default.
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