Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265820530> ?p ?o ?g. }
- W2265820530 endingPage "33" @default.
- W2265820530 startingPage "24" @default.
- W2265820530 abstract "MicroRNA-129-1 (miR-129-1) seems to behave as a tumour suppressor since its decreased expression is associated with different tumours such as glioblastoma multiforme (GBM). GBM is the most common form of brain tumours originating from glial cells. The impact of miR-129-1 downregulation on GBM pathogenesis has yet to be elucidated.MiR-129-1 was overexpressed in GBM cells, and its effect on proliferation was investigated by cell cycle assay. MiR-129-1 predicted targets (CDK6, IGF1, HDAC2, IGF2BP3 and MAPK1) were also evaluated by western blot and luciferase assay.Restoration of miR-129-1 reduced cell proliferation and induced G1 accumulation, significantly. Several functional assays confirmed IGF2BP3, MAPK1 and CDK6 as targets of miR-129-1. Despite the fact that IGF1 expression can be suppressed by miR-129-1, through 3'-untranslated region complementary sequence, we could not find any association between IGF1 expression and GBM. MiR-129-1 expression inversely correlates with CDK6, IGF2BP3 and MAPK1 in primary clinical samples.This is the first study to propose miR129-1 as a negative regulator of IGF2BP3 and MAPK1 and also a cell cycle arrest inducer in GBM cells. Our data suggests miR-129-1 as a potential tumour suppressor and presents a rationale for the use of miR-129-1 as a novel strategy to improve treatment response in GBM." @default.
- W2265820530 created "2016-06-24" @default.
- W2265820530 creator A5013329396 @default.
- W2265820530 creator A5013861101 @default.
- W2265820530 creator A5014954466 @default.
- W2265820530 creator A5016802606 @default.
- W2265820530 creator A5030558790 @default.
- W2265820530 creator A5032654749 @default.
- W2265820530 creator A5058919540 @default.
- W2265820530 creator A5079338250 @default.
- W2265820530 creator A5080086182 @default.
- W2265820530 creator A5085895836 @default.
- W2265820530 creator A5087958816 @default.
- W2265820530 creator A5088734716 @default.
- W2265820530 date "2015-10-28" @default.
- W2265820530 modified "2023-10-12" @default.
- W2265820530 title "MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1" @default.
- W2265820530 cites W1540320516 @default.
- W2265820530 cites W1972840121 @default.
- W2265820530 cites W1974234783 @default.
- W2265820530 cites W1976059452 @default.
- W2265820530 cites W1978561866 @default.
- W2265820530 cites W1983833034 @default.
- W2265820530 cites W1985563073 @default.
- W2265820530 cites W1985960583 @default.
- W2265820530 cites W1988023818 @default.
- W2265820530 cites W1989449643 @default.
- W2265820530 cites W2000077530 @default.
- W2265820530 cites W2014610388 @default.
- W2265820530 cites W2016715353 @default.
- W2265820530 cites W2033473290 @default.
- W2265820530 cites W2036044314 @default.
- W2265820530 cites W2042681244 @default.
- W2265820530 cites W2047589007 @default.
- W2265820530 cites W2051936761 @default.
- W2265820530 cites W2052209686 @default.
- W2265820530 cites W2055206990 @default.
- W2265820530 cites W2056687236 @default.
- W2265820530 cites W2058273511 @default.
- W2265820530 cites W2061224512 @default.
- W2265820530 cites W2067588941 @default.
- W2265820530 cites W2073620078 @default.
- W2265820530 cites W2074114726 @default.
- W2265820530 cites W2076542702 @default.
- W2265820530 cites W2081236313 @default.
- W2265820530 cites W2084120869 @default.
- W2265820530 cites W2098425296 @default.
- W2265820530 cites W2109227959 @default.
- W2265820530 cites W2113445340 @default.
- W2265820530 cites W2128219894 @default.
- W2265820530 cites W2130026057 @default.
- W2265820530 cites W2139791626 @default.
- W2265820530 cites W2140958498 @default.
- W2265820530 cites W2146257697 @default.
- W2265820530 cites W2151939392 @default.
- W2265820530 cites W2163587546 @default.
- W2265820530 cites W2165685844 @default.
- W2265820530 cites W2165692147 @default.
- W2265820530 cites W4294216483 @default.
- W2265820530 doi "https://doi.org/10.1136/jmedgenet-2015-103225" @default.
- W2265820530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26510428" @default.
- W2265820530 hasPublicationYear "2015" @default.
- W2265820530 type Work @default.
- W2265820530 sameAs 2265820530 @default.
- W2265820530 citedByCount "55" @default.
- W2265820530 countsByYear W22658205302016 @default.
- W2265820530 countsByYear W22658205302017 @default.
- W2265820530 countsByYear W22658205302018 @default.
- W2265820530 countsByYear W22658205302019 @default.
- W2265820530 countsByYear W22658205302020 @default.
- W2265820530 countsByYear W22658205302021 @default.
- W2265820530 countsByYear W22658205302022 @default.
- W2265820530 countsByYear W22658205302023 @default.
- W2265820530 crossrefType "journal-article" @default.
- W2265820530 hasAuthorship W2265820530A5013329396 @default.
- W2265820530 hasAuthorship W2265820530A5013861101 @default.
- W2265820530 hasAuthorship W2265820530A5014954466 @default.
- W2265820530 hasAuthorship W2265820530A5016802606 @default.
- W2265820530 hasAuthorship W2265820530A5030558790 @default.
- W2265820530 hasAuthorship W2265820530A5032654749 @default.
- W2265820530 hasAuthorship W2265820530A5058919540 @default.
- W2265820530 hasAuthorship W2265820530A5079338250 @default.
- W2265820530 hasAuthorship W2265820530A5080086182 @default.
- W2265820530 hasAuthorship W2265820530A5085895836 @default.
- W2265820530 hasAuthorship W2265820530A5087958816 @default.
- W2265820530 hasAuthorship W2265820530A5088734716 @default.
- W2265820530 hasBestOaLocation W22658205301 @default.
- W2265820530 hasConcept C104317684 @default.
- W2265820530 hasConcept C105696609 @default.
- W2265820530 hasConcept C121608353 @default.
- W2265820530 hasConcept C124320809 @default.
- W2265820530 hasConcept C127561419 @default.
- W2265820530 hasConcept C145059251 @default.
- W2265820530 hasConcept C1491633281 @default.
- W2265820530 hasConcept C179185449 @default.
- W2265820530 hasConcept C199649820 @default.
- W2265820530 hasConcept C29537977 @default.
- W2265820530 hasConcept C502942594 @default.