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- W2265945699 endingPage "20140185" @default.
- W2265945699 startingPage "20140185" @default.
- W2265945699 abstract "Dopamine (DA) is a key transmitter in motor, reward and cogitative pathways, with DA dysfunction implicated in disorders including Parkinson's disease and addiction. Located in midbrain, DA neurons of the substantia nigra pars compacta project via the medial forebrain bundle to the dorsal striatum (caudate putamen), and DA neurons in the adjacent ventral tegmental area project to the ventral striatum (nucleus accumbens) and prefrontal cortex. In addition to classical vesicular release from axons, midbrain DA neurons exhibit DA release from their cell bodies and dendrites. Somatodendritic DA release leads to activation of D2 DA autoreceptors on DA neurons that inhibit their firing via G-protein-coupled inwardly rectifying K(+) channels. This helps determine patterns of DA signalling at distant axonal release sites. Somatodendritically released DA also acts via volume transmission to extrasynaptic receptors that modulate local transmitter release and neuronal activity in the midbrain. Thus, somatodendritic release is a pivotal intrinsic feature of DA neurons that must be well defined in order to fully understand the physiology and pathophysiology of DA pathways. Here, we review recent mechanistic aspects of somatodendritic DA release, with particular emphasis on the Ca(2+) dependence of release and the potential role of exocytotic proteins." @default.
- W2265945699 created "2016-06-24" @default.
- W2265945699 creator A5043025373 @default.
- W2265945699 creator A5064808723 @default.
- W2265945699 date "2015-07-05" @default.
- W2265945699 modified "2023-10-16" @default.
- W2265945699 title "Somatodendritic dopamine release: recent mechanistic insights" @default.
- W2265945699 cites W1238819995 @default.
- W2265945699 cites W1482599777 @default.
- W2265945699 cites W1504622309 @default.
- W2265945699 cites W1507545195 @default.
- W2265945699 cites W1510439895 @default.
- W2265945699 cites W1525576457 @default.
- W2265945699 cites W1533708729 @default.
- W2265945699 cites W1544848013 @default.
- W2265945699 cites W1546941611 @default.
- W2265945699 cites W1567696719 @default.
- W2265945699 cites W1572935117 @default.
- W2265945699 cites W1589264845 @default.
- W2265945699 cites W1607531583 @default.
- W2265945699 cites W1625996387 @default.
- W2265945699 cites W1656933259 @default.
- W2265945699 cites W1724599310 @default.
- W2265945699 cites W177723524 @default.
- W2265945699 cites W1803352854 @default.
- W2265945699 cites W1818998151 @default.
- W2265945699 cites W1823302046 @default.
- W2265945699 cites W1861338253 @default.
- W2265945699 cites W1863384211 @default.
- W2265945699 cites W1906108053 @default.
- W2265945699 cites W1906815697 @default.
- W2265945699 cites W1910298002 @default.
- W2265945699 cites W1925686653 @default.
- W2265945699 cites W1966343623 @default.
- W2265945699 cites W1968748677 @default.
- W2265945699 cites W1969587147 @default.
- W2265945699 cites W1970846389 @default.
- W2265945699 cites W1971573997 @default.
- W2265945699 cites W1971840849 @default.
- W2265945699 cites W1973747047 @default.
- W2265945699 cites W1977775362 @default.
- W2265945699 cites W1980682773 @default.
- W2265945699 cites W1982202989 @default.
- W2265945699 cites W1983005307 @default.
- W2265945699 cites W1986097748 @default.
- W2265945699 cites W1987311156 @default.
- W2265945699 cites W1987762853 @default.
- W2265945699 cites W1988519618 @default.
- W2265945699 cites W1988578216 @default.
- W2265945699 cites W1989123260 @default.
- W2265945699 cites W1989486566 @default.
- W2265945699 cites W1990556558 @default.
- W2265945699 cites W1993415904 @default.
- W2265945699 cites W1995231534 @default.
- W2265945699 cites W1997695958 @default.
- W2265945699 cites W1998939463 @default.
- W2265945699 cites W1999127620 @default.
- W2265945699 cites W1999667319 @default.
- W2265945699 cites W2003168086 @default.
- W2265945699 cites W2004156074 @default.
- W2265945699 cites W2004481724 @default.
- W2265945699 cites W2004934156 @default.
- W2265945699 cites W2005674083 @default.
- W2265945699 cites W2007646404 @default.
- W2265945699 cites W2008438340 @default.
- W2265945699 cites W2010279907 @default.
- W2265945699 cites W2010730632 @default.
- W2265945699 cites W2013022391 @default.
- W2265945699 cites W2013872218 @default.
- W2265945699 cites W2016558598 @default.
- W2265945699 cites W2016958461 @default.
- W2265945699 cites W2017688838 @default.
- W2265945699 cites W2018798878 @default.
- W2265945699 cites W2020484733 @default.
- W2265945699 cites W2021272772 @default.
- W2265945699 cites W2021724192 @default.
- W2265945699 cites W2023873312 @default.
- W2265945699 cites W2024905528 @default.
- W2265945699 cites W2026339353 @default.
- W2265945699 cites W2026488144 @default.
- W2265945699 cites W2027352134 @default.
- W2265945699 cites W2028619376 @default.
- W2265945699 cites W2032471499 @default.
- W2265945699 cites W2034380639 @default.
- W2265945699 cites W2035089487 @default.
- W2265945699 cites W2037500812 @default.
- W2265945699 cites W2040224852 @default.
- W2265945699 cites W2042335457 @default.
- W2265945699 cites W2042504555 @default.
- W2265945699 cites W2046302119 @default.
- W2265945699 cites W2047790410 @default.
- W2265945699 cites W2048465987 @default.
- W2265945699 cites W2050457197 @default.
- W2265945699 cites W2050724215 @default.
- W2265945699 cites W2051572005 @default.
- W2265945699 cites W2051841169 @default.
- W2265945699 cites W2053928819 @default.
- W2265945699 cites W2054075548 @default.