Matches in SemOpenAlex for { <https://semopenalex.org/work/W2265992527> ?p ?o ?g. }
- W2265992527 endingPage "139" @default.
- W2265992527 startingPage "139" @default.
- W2265992527 abstract "(1) BACKGROUND: Alstonia scholaris (Apocynaceae) is an important medicinal plant that has been historically used in Dai ethnopharmacy to treat infectious diseases in China. Although various pharmacological activities have been reported, the antimicrobial constitutes of A. scholaris have not yet been identified. The objective of this study is to evaluate the antibacterial constitutes from the leaf extract of A. scholaris and to assess the synergistic effects of isolated compounds with antibiotics against bacterial pathogens.; (2) METHODS: The chemical constitutes isolated from the leaf extract of A. scholaris were structurally identified by NMR. The antibacterial and synergistic effect of compounds was assessed by calculating the minimal inhibitory concentration (MIC), checkerboard dilution test, and time-kill assay.; (3) RESULTS: Six pentacyclic triterpenoids were structurally identified as (1) lupeol, (2) betulin, (3) 3-hydroxy-11-ursen-28,13-olide, (4) betulinic acid, (5) oleanolic acid and (6) ursolic acid. Both oleanolic and ursolic acid showed antibacterial activity but were limited to Gram-positive bacteria. Ursolic acid showed a synergistic effect with ampicillin and tetracycline against both Bacillus cereus and S. aureus.; (4) CONCLUSION: These findings reflect that pentacyclic triterpenoids are the antibacterial chemicals in A. scholaris. The ability of ursolic acid to enhance the activity of antibiotics can constitute a valuable group of therapeutic agents in the future." @default.
- W2265992527 created "2016-06-24" @default.
- W2265992527 creator A5015253235 @default.
- W2265992527 creator A5019669828 @default.
- W2265992527 creator A5021747743 @default.
- W2265992527 creator A5049185409 @default.
- W2265992527 creator A5057776501 @default.
- W2265992527 creator A5090147809 @default.
- W2265992527 date "2016-01-25" @default.
- W2265992527 modified "2023-10-07" @default.
- W2265992527 title "Antibacterial and Synergistic Activity of Pentacyclic Triterpenoids Isolated from Alstonia scholaris" @default.
- W2265992527 cites W1494734453 @default.
- W2265992527 cites W1967002934 @default.
- W2265992527 cites W1972314759 @default.
- W2265992527 cites W1973147826 @default.
- W2265992527 cites W1974561175 @default.
- W2265992527 cites W1988019359 @default.
- W2265992527 cites W1990872166 @default.
- W2265992527 cites W1999040660 @default.
- W2265992527 cites W2002092334 @default.
- W2265992527 cites W2003772112 @default.
- W2265992527 cites W2005854408 @default.
- W2265992527 cites W2008834312 @default.
- W2265992527 cites W2015247449 @default.
- W2265992527 cites W2015381731 @default.
- W2265992527 cites W2016562927 @default.
- W2265992527 cites W2025632215 @default.
- W2265992527 cites W2033930925 @default.
- W2265992527 cites W2036544384 @default.
- W2265992527 cites W2040084056 @default.
- W2265992527 cites W2041950913 @default.
- W2265992527 cites W2048967802 @default.
- W2265992527 cites W2049435714 @default.
- W2265992527 cites W2069485152 @default.
- W2265992527 cites W2073419937 @default.
- W2265992527 cites W2081527040 @default.
- W2265992527 cites W2088268075 @default.
- W2265992527 cites W2095735547 @default.
- W2265992527 cites W2098638379 @default.
- W2265992527 cites W2101650905 @default.
- W2265992527 cites W2110837175 @default.
- W2265992527 cites W2118970688 @default.
- W2265992527 cites W2128834033 @default.
- W2265992527 cites W2141378337 @default.
- W2265992527 cites W2156212552 @default.
- W2265992527 cites W2165861026 @default.
- W2265992527 cites W2326236900 @default.
- W2265992527 cites W4239569810 @default.
- W2265992527 doi "https://doi.org/10.3390/molecules21020139" @default.
- W2265992527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6273878" @default.
- W2265992527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26821000" @default.
- W2265992527 hasPublicationYear "2016" @default.
- W2265992527 type Work @default.
- W2265992527 sameAs 2265992527 @default.
- W2265992527 citedByCount "65" @default.
- W2265992527 countsByYear W22659925272016 @default.
- W2265992527 countsByYear W22659925272017 @default.
- W2265992527 countsByYear W22659925272018 @default.
- W2265992527 countsByYear W22659925272019 @default.
- W2265992527 countsByYear W22659925272020 @default.
- W2265992527 countsByYear W22659925272021 @default.
- W2265992527 countsByYear W22659925272022 @default.
- W2265992527 countsByYear W22659925272023 @default.
- W2265992527 crossrefType "journal-article" @default.
- W2265992527 hasAuthorship W2265992527A5015253235 @default.
- W2265992527 hasAuthorship W2265992527A5019669828 @default.
- W2265992527 hasAuthorship W2265992527A5021747743 @default.
- W2265992527 hasAuthorship W2265992527A5049185409 @default.
- W2265992527 hasAuthorship W2265992527A5057776501 @default.
- W2265992527 hasAuthorship W2265992527A5090147809 @default.
- W2265992527 hasBestOaLocation W22659925271 @default.
- W2265992527 hasConcept C142724271 @default.
- W2265992527 hasConcept C185592680 @default.
- W2265992527 hasConcept C204787440 @default.
- W2265992527 hasConcept C2777829905 @default.
- W2265992527 hasConcept C2778509883 @default.
- W2265992527 hasConcept C2778858181 @default.
- W2265992527 hasConcept C2779513101 @default.
- W2265992527 hasConcept C2779782153 @default.
- W2265992527 hasConcept C2780007248 @default.
- W2265992527 hasConcept C2780104969 @default.
- W2265992527 hasConcept C2780527577 @default.
- W2265992527 hasConcept C4937899 @default.
- W2265992527 hasConcept C523546767 @default.
- W2265992527 hasConcept C54355233 @default.
- W2265992527 hasConcept C55493867 @default.
- W2265992527 hasConcept C556039675 @default.
- W2265992527 hasConcept C59822182 @default.
- W2265992527 hasConcept C71924100 @default.
- W2265992527 hasConcept C86803240 @default.
- W2265992527 hasConcept C89423630 @default.
- W2265992527 hasConceptScore W2265992527C142724271 @default.
- W2265992527 hasConceptScore W2265992527C185592680 @default.
- W2265992527 hasConceptScore W2265992527C204787440 @default.
- W2265992527 hasConceptScore W2265992527C2777829905 @default.
- W2265992527 hasConceptScore W2265992527C2778509883 @default.
- W2265992527 hasConceptScore W2265992527C2778858181 @default.
- W2265992527 hasConceptScore W2265992527C2779513101 @default.