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- W2266027323 abstract "Lack of knowledge on the biology of renal epithelial cells is hampering urgently needed applications of cell-based therapies for renal disease. This chapter reviews recent efforts toward the generation of in vitro renal organotypic cultures. It starts by discussing protocols for isolation and culture of phenotypically differentiated renal epithelial cells, including their generation from stem cells. It then explains procedures and materials employed to simulate cell interactions with extracellular matrix and other cells. The chapter ends by presenting microfluidics as a unique technology to integrate luminal flow with 3D physical and chemical environment into a biomimicking cell culture device. Such a model will allow a leap forward in understanding critical parameters of renal epithelial function that will subsequently be applied into bioartificial kidney and other cell-based therapies in renal regenerative medicine, besides providing better drug and nephrotoxicity screening assays." @default.
- W2266027323 created "2016-06-24" @default.
- W2266027323 creator A5020650531 @default.
- W2266027323 creator A5061023602 @default.
- W2266027323 creator A5072288536 @default.
- W2266027323 date "2016-01-01" @default.
- W2266027323 modified "2023-09-22" @default.
- W2266027323 title "Microfluidic-Based 3D Models of Renal Function for Clinically Oriented Research" @default.
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