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• W2266057742 abstract "Abstract 1.1. Immunoprecipitation is a useful and precise method for measuring the concentration of gamma globulins in human sera. Its principal value is in the study of hypogammaglobulinemic sera, for which precise measurement of very small quantities of gamma globulins is of importance. 2.2. Other methods of quantitating gamma globulins, such as salting out, turbidity, and electrophoretic techniques, are incapable of the precise measurement of low concentrations of gamma globulins which can be obtained by immunologic methods. 3.3. Essential to the immunoprecipitation method is the availability of an antiserum capable of precipitating with all the gamma globulins but not with other serum components. Agar techniques may fail to indicate correctly the presence or absence of undesired contaminant antibodies which will precipitate serum components other than gamma globulins. 4.4. Contaminant antibodies can be detected by the study of the precipitation curve obtained when antiserum is reacted with high dilutions of hypogammaglobulinemic serum. These antibodies can be removed by adsorption with hypogammaglobulinemic serum. 5.5. Each batch of antiserum must be calibrated by means of a standard solution of gamma globulin and the range of normal values must be evaluated with sera of known concentration of gamma globulins. 6.6. Concentrations of gamma globulins obtained when normal sera were quantitated by immunoprecipitation tended to be higher than corresponding values obtained when the same sera were analyzed by electrophoretic methods. Probably this difference was due to the presence of proteins which reacted immunologically as gamma globulins but which, during electrophoresis, migrated more rapidly than the bulk of gamma globulins. 7.7. Immunoprecipitation was capable of measuring levels of gamma globulins as low as 1 to 5 mg. per 100 ml. with excellent reproducibility. When hypogammaglobulinemic sera were quantitated with the use of a single batch of anti-serum, the coefficients of variation ranged from 5 to 7. There is no absolute standard against which these determinations could be compared, but there can be little doubt that they represented a true measure of the immunologically active gamma globulins present." @default.
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• W2266057742 date "1960-04-01" @default.
• W2266057742 modified "2023-09-23" @default.
• W2266057742 title "Quantitation of gamma globulins in human serum by immunoprecipitation." @default.
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